DegronMD - Q9Y2D9(ZNF652)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S216R	TCGA-61-2008	OV	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation blocking phosphorylation signal	0.6111
p.S216R	DO29658	OV	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation blocking phosphorylation signal	0.6111
p.R213H	TCGA-B5-A11E	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.25
p.R213H	TCGA-B5-A11E	UCEC	TCGA	AATTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0833
p.R213H	DO41644	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.25
p.R213H	DO41644	UCEC	ICGC	AATTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0833
p.S216G	TCGA-BR-A4J7	STAD	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation blocking phosphorylation signal	0.6111
p.S216G	DO47953	STAD	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation blocking phosphorylation signal	0.6111
p.A200V	TCGA-CG-5721	STAD	TCGA	AATTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5825
p.A200V	DO38192	STAD	ICGC	AATTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.5825
p.V217G	TCGA-CV-7432	HNSC	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.1389
p.V217G	DO14159	HNSC	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.1389
p.S511F	TCGA-D3-A5GO	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7982
p.S511F	DO47419	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7982
p.P497L	TCGA-D3-A8GB	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0556
p.P497L	DO50280	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0556
p.T210A	TCGA-DI-A1BU	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation altering degron motif	0.7139
p.T210A	DO42023	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation altering degron motif	0.7139
p.V519A	TCGA-E2-A15M	BRCA	TCGA	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.V519A	TCGA-E2-A15M	BRCA	TCGA	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1111
p.V519A	DO2026	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.3056
p.V519A	DO2026	BRCA	ICGC	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1111
p.P526S	TCGA-EE-A2GT	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1111
p.P526S	DO37946	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1111
p.P526T	TCGA-EE-A2MM	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1111
p.P526T	DO37770	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.1111
p.P219L	TCGA-EO-A22X	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.0833
p.P219L	DO43907	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.0833
p.P517S	TCGA-FR-A8YC	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5641
p.P517S	DO50301	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5641
p.R213C	TCGA-FS-A1ZA	SKCM	TCGA	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.25
p.R213C	TCGA-FS-A1ZA	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0833
p.R213C	DO37551	SKCM	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.25
p.R213C	DO37551	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	200:204	Mutation rewiring degron network	0.0833
p.P517T	DO225215	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5919
p.P517T	DO227836	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5919
p.P219S	DO233951	GACA	ICGC	PTPRTT	DEG_SCF_FBW7_1	205:210	Mutation rewiring degron network	0.0833
p.N521K	DO229025	LICA	ICGC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.25
p.N521K	DO229025	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.0556
p.T192N	DO229031	LICA	ICGC	AATTS	DEG_SPOP_SBC_1	200:204	Mutation blocking phosphorylation signal	0.5556
p.A200T	SIDM00849	Kidney Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	200:204	Mutation altering degron motif	0.7139
p.V516F	SIDM01257	Hepatocellular Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5957
p.V516F	SIDM00062	Hepatocellular Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5957
p.V516F	ACH-000671	Liver Cancer	CCLE	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5957
p.V516F	ACH-002395	Liver Cancer	CCLE	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5957
p.V516F	HUH-6-clone5	liver	COSMIC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation altering degron motif	0.5957
p.T527I	SIDM00720	Mesothelioma	GDSC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.0833
p.T527I	SIDM00760	Small Cell Lung Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	512:518	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF652

UniProt ID: Q9Y2D9

Entrez ID: 22834

Protein name: Zinc finger protein 652

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF652 in