DegronMD

Uniprot ID: Q9Y2D9

Source protein: Zinc finger protein 652

Source gene: ZNF652

Class: DEG_SCF_FBW7_1

Location: 512:518

E3 ligase: FBXW7

DEGRON score: 0.6745

ASA_SCORE: 83.2429

COIL: 0.781

CONS_SCORE: 0.6546

DSS_SCORE: 0.4672

HELIX: 0.0287

FCONS_SCORE: 0.855

RIG_SCORE: 0.6753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V519A	TCGA-E2-A15M	BRCA	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.3056
p.V519A	DO2026	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.3056
p.P526S	TCGA-EE-A2GT	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.1111
p.P526S	DO37946	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.1111
p.P526T	TCGA-EE-A2MM	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.1111
p.P526T	DO37770	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.1111
p.P517S	TCGA-FR-A8YC	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.5641
p.P517S	DO50301	SKCM	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.5641
p.P517T	DO225215	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.5919
p.P517T	DO227836	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.5919
p.N521K	DO229025	LICA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.25
p.V516F	SIDM01257	Hepatocellular Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	0.5957
p.V516F	SIDM00062	Hepatocellular Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	0.5957
p.V516F	ACH-000671	Liver Cancer	CCLE	PATPVPS	DEG_SCF_FBW7_1	0.5957
p.V516F	ACH-002395	Liver Cancer	CCLE	PATPVPS	DEG_SCF_FBW7_1	0.5957
p.V516F	HUH-6-clone5	liver	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.5957
p.T527I	SIDM00720	Mesothelioma	GDSC	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.T527I	SIDM00760	Small Cell Lung Carcinoma	GDSC	PATPVPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92993	Histone acetyltransferase KAT5	DEG_SCF_FBW7_1	156:162	PATPVPS	FBXW7	0.9978	More...
Q9Y2D9	Zinc finger protein 652	DEG_SCF_FBW7_1	512:518	PATPVPS	FBXW7	0.6745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons