DegronMD

Uniprot ID: Q92993

Source protein: Histone acetyltransferase KAT5

Source gene: KAT5

Class: DEG_SCF_FBW7_1

Location: 156:162

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 87

COIL: 0.9443

CONS_SCORE: 0.2531

DSS_SCORE: 0.541

HELIX: 0.0267

FCONS_SCORE: 1.0268

RIG_SCORE: 0.645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E154D	TCGA-86-8585	LUAD	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.2778
p.G160S	TCGA-B5-A3FC	UCEC	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.6993
p.R155L	TCGA-FS-A1ZR	SKCM	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.75
p.S168F	TCGA-K4-A6MB	BLCA	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.1667
p.S171F	TCGA-K4-A6MB	BLCA	TCGA	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.S171F	DO44077	BLCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.R168Q	DO3958	BRCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.1667
p.D171N	DO44377	CESC	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.D171N	DO222601	ESCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.D171N	DO13863	GBM	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0833
p.R159H	DO222765	COCA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.8244
p.R159H	DO41331	UCEC	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.8244
p.D146Y	DO22237	LGG	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0556
p.S163I	DO228986	LICA	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.3056
p.R159C	DO43338	UCEC	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.8301
p.D172V	DO41235	UCEC	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0556
p.D172N	DO41199	UCEC	ICGC	PATPVPS	DEG_SCF_FBW7_1	0.0556
p.V169I	ACH-002263	Esophageal Cancer	CCLE	PATPVPS	DEG_SCF_FBW7_1	0.1389
p.V169I	KYSE-220	oesophagus	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.1389
p.R158H	SNU-1040	large_intestine	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.8244
p.V150I	KYSE-220	oesophagus	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.2778
p.Y165N	NCI-H446	lung	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.25
p.R159G	GI-1	central_nervous_system	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.7568
p.G171D	NCI-H630	large_intestine	COSMIC	PATPVPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92993	Histone acetyltransferase KAT5	DEG_SCF_FBW7_1	156:162	PATPVPS	FBXW7	0.9978	More...
Q9Y2D9	Zinc finger protein 652	DEG_SCF_FBW7_1	512:518	PATPVPS	FBXW7	0.6745	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons