DegronMD

Uniprot ID: Q9Y2D9

Source protein: Zinc finger protein 652

Source gene: ZNF652

Class: DEG_SCF_FBW7_1

Location: 205:210

E3 ligase: FBXW7

DEGRON score: 0.5274

ASA_SCORE: 108.9833

COIL: 0.8705

CONS_SCORE: 0.758

DSS_SCORE: 0.7906

HELIX: 0.0165

FCONS_SCORE: 0.9578

RIG_SCORE: 0.6245

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S216R	TCGA-61-2008	OV	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.6111
p.S216R	DO29658	OV	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.6111
p.R213H	TCGA-B5-A11E	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.25
p.R213H	DO41644	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.25
p.S216G	TCGA-BR-A4J7	STAD	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.6111
p.S216G	DO47953	STAD	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.6111
p.V217G	TCGA-CV-7432	HNSC	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.1389
p.V217G	DO14159	HNSC	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.1389
p.T210A	TCGA-DI-A1BU	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.7139
p.T210A	DO42023	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.7139
p.P219L	TCGA-EO-A22X	UCEC	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.0833
p.P219L	DO43907	UCEC	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.0833
p.R213C	TCGA-FS-A1ZA	SKCM	TCGA	PTPRTT	DEG_SCF_FBW7_1	0.25
p.R213C	DO37551	SKCM	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.25
p.P219S	DO233951	GACA	ICGC	PTPRTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2D9	Zinc finger protein 652	DEG_SCF_FBW7_1	205:210	PTPRTT	FBXW7	0.5274	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons