DegronMD - Q9BQ04(RBM4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A293T	TCGA-A6-6780	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.6028
p.A293T	DO10244	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.6028
p.R347W	TCGA-BR-4256	STAD	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2222
p.R347W	DO38743	STAD	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2222
p.M342I	TCGA-BT-A20J	BLCA	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6507
p.M342I	DO457	BLCA	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6507
p.D341G	TCGA-CG-5721	STAD	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6087
p.D341G	DO38192	STAD	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6087
p.A292T	TCGA-CG-5721	STAD	TCGA	AATTS	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7139
p.A292T	DO38192	STAD	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7139
p.A333T	TCGA-D1-A17Q	UCEC	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2778
p.A333T	DO41903	UCEC	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.2778
p.P305Q	TCGA-D3-A2J6	SKCM	TCGA	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.0833
p.P305Q	DO37901	SKCM	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.0833
p.L328F	TCGA-DJ-A1QO	THCA	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1389
p.L328F	DO40456	THCA	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.1389
p.R336L	TCGA-EE-A29E	SKCM	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.8428
p.R336L	DO37831	SKCM	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.8428
p.D302G	TCGA-G4-6588	COAD	TCGA	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.D302G	DO10140	COAD	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.S297C	TCGA-PL-A8LV	BRCA	TCGA	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.3056
p.S297C	DO51215	BRCA	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.3056
p.A289T	DO233882	GACA	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.25
p.V268A	DO228950	LICA	ICGC	VQSTT	DEG_SPOP_SBC_1	254:258	Mutation rewiring degron network	0.0556
p.D302N	DO222710	MELA	ICGC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.P305T	SIDM01943	Colorectal Carcinoma	GDSC	AATTS	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.0833
p.R353Q	SIDM00845	Burkitt's Lymphoma	GDSC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.R353Q	ACH-000786	Lymphoma	CCLE	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.R353Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation rewiring degron network	0.0556
p.M342V	SIDM00522	Small Cell Lung Carcinoma	GDSC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6097
p.M342V	DMS-273	lung	COSMIC	TRNSLYDMA	DEG_APCC_DBOX_1	335:343	Mutation altering degron motif	0.6097

Kaplan plot for RBM4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM4B

UniProt ID: Q9BQ04

Entrez ID: 83759

Protein name: RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM4B in