DegronMD

Uniprot ID: Q9BQ04

Source protein: RNA-binding protein 4B

Source gene: RBM4B

Class: DEG_APCC_DBOX_1

Location: 335:343

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 81.3

COIL: 0.563

CONS_SCORE: 0.4066

DSS_SCORE: 0.3442

HELIX: 0.421

FCONS_SCORE: 1.0319

RIG_SCORE: 0.795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R347W	TCGA-BR-4256	STAD	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.2222
p.R347W	DO38743	STAD	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.2222
p.M342I	TCGA-BT-A20J	BLCA	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.6507
p.M342I	DO457	BLCA	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.6507
p.D341G	TCGA-CG-5721	STAD	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.6087
p.D341G	DO38192	STAD	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.6087
p.A333T	TCGA-D1-A17Q	UCEC	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.2778
p.A333T	DO41903	UCEC	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.2778
p.L328F	TCGA-DJ-A1QO	THCA	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.1389
p.L328F	DO40456	THCA	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.1389
p.R336L	TCGA-EE-A29E	SKCM	TCGA	TRNSLYDMA	DEG_APCC_DBOX_1	0.8428
p.R336L	DO37831	SKCM	ICGC	TRNSLYDMA	DEG_APCC_DBOX_1	0.8428
p.R353Q	SIDM00845	Burkitt's Lymphoma	GDSC	TRNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.R353Q	ACH-000786	Lymphoma	CCLE	TRNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.R353Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	TRNSLYDMA	DEG_APCC_DBOX_1	0.0556
p.M342V	SIDM00522	Small Cell Lung Carcinoma	GDSC	TRNSLYDMA	DEG_APCC_DBOX_1	0.6097
p.M342V	DMS-273	lung	COSMIC	TRNSLYDMA	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BQ04	RNA-binding protein 4B	DEG_APCC_DBOX_1	335:343	TRNSLYDMA	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons