DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VQSTT
Uniprot ID:
Q9BQ04
Source protein:
RNA-binding protein 4B
Source gene:
RBM4B
Class:
DEG_SPOP_SBC_1
Location:
254:258
E3 ligase:
SPOP
DEGRON score:
0.9245
ASA_SCORE:
89.06
COIL:
0.9114
CONS_SCORE:
0.3599
DSS_SCORE:
0.4783
HELIX:
0.0626
FCONS_SCORE:
1.0699
RIG_SCORE:
0.6974
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V268A
DO228950
LICA
ICGC
VQSTT
DEG_SPOP_SBC_1
0.0556
Drug responses associated with RBM4B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P52597
Heterogeneous nuclear ribonucleoprotein F
DEG_SPOP_SBC_1
283:287
VQSTT
SPOP
0.7786
More...
Q9BQ04
RNA-binding protein 4B
DEG_SPOP_SBC_1
254:258
VQSTT
SPOP
0.9245
More...