DegronMD - P52597(HNRNPF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M293I	TCGA-18-3409	LUSC	TCGA	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1667
p.M293I	DO26444	LUSC	ICGC	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1667
p.N307Y	TCGA-22-1012	LUSC	TCGA	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation rewiring degron network	0.1111
p.N307Y	DO27302	LUSC	ICGC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation rewiring degron network	0.1111
p.R275K	TCGA-CV-7414	HNSC	TCGA	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1111
p.R275K	DO15631	HNSC	ICGC	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1111
p.E320Q	TCGA-D8-A27V	BRCA	TCGA	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.6744
p.E320Q	DO6048	BRCA	ICGC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.6744
p.H292Q	TCGA-OR-A5J7	ACC	TCGA	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1944
p.P297S	TCGA-QG-A5Z2	COAD	TCGA	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0556
p.P297S	DO44096	COAD	ICGC	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.0556
p.T328M	DO224980	BRCA	ICGC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation rewiring degron network	0.1111
p.E280K	DO223126	ESCA	ICGC	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.25
p.Y306C	DO233207	GACA	ICGC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation blocking phosphorylation signal	0.5278
p.I319V	DO23264	LINC	ICGC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.5965
p.G277S	DO232973	PEME	ICGC	VQSTT	DEG_SPOP_SBC_1	283:287	Mutation rewiring degron network	0.1667
p.V315M	SIDM00193	Colorectal Carcinoma	GDSC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.6097
p.V315M	ACH-000991	Colon/Colorectal Cancer	CCLE	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.6097
p.V315M	SNU-81	large intestine	COSMIC	VRVHIE	LIG_APCC_ABBA_1	315:320	Mutation altering degron motif	0.6097

Kaplan plot for HNRNPF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HNRNPF

UniProt ID: P52597

Entrez ID: 3185

Protein name: Heterogeneous nuclear ribonucleoprotein F (hnRNP F) (Nucleolin-like protein mcs94-1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein F, N-terminally processed]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HNRNPF in