DegronMD

Uniprot ID: P52597

Source protein: Heterogeneous nuclear ribonucleoprotein F

Source gene: HNRNPF

Class: LIG_APCC_ABBA_1

Location: 315:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7932

ASA_SCORE: 37.95

COIL: 0.1067

CONS_SCORE: 0.4593

DSS_SCORE: 0.274

HELIX: 0.006

FCONS_SCORE: 0.7725

RIG_SCORE: 0.829

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N307Y	TCGA-22-1012	LUSC	TCGA	VRVHIE	LIG_APCC_ABBA_1	0.1111
p.N307Y	DO27302	LUSC	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.1111
p.E320Q	TCGA-D8-A27V	BRCA	TCGA	VRVHIE	LIG_APCC_ABBA_1	0.6744
p.E320Q	DO6048	BRCA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.6744
p.T328M	DO224980	BRCA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.1111
p.Y306C	DO233207	GACA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.5278
p.I319V	DO23264	LINC	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.5965
p.V315M	SIDM00193	Colorectal Carcinoma	GDSC	VRVHIE	LIG_APCC_ABBA_1	0.6097
p.V315M	ACH-000991	Colon/Colorectal Cancer	CCLE	VRVHIE	LIG_APCC_ABBA_1	0.6097
p.V315M	SNU-81	large_intestine	COSMIC	VRVHIE	LIG_APCC_ABBA_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31943	Heterogeneous nuclear ribonucleoprotein H	LIG_APCC_ABBA_1	315:320	VRVHIE	APC,CDC20,FZR1	0.7541	More...
P52597	Heterogeneous nuclear ribonucleoprotein F	LIG_APCC_ABBA_1	315:320	VRVHIE	APC,CDC20,FZR1	0.7932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons