DegronMD

Uniprot ID: P31943

Source protein: Heterogeneous nuclear ribonucleoprotein H

Source gene: HNRNPH1

Class: LIG_APCC_ABBA_1

Location: 315:320

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7541

ASA_SCORE: 38.7333

COIL: 0.1158

CONS_SCORE: 0.46

DSS_SCORE: 0.2717

HELIX: 0.0063

FCONS_SCORE: 0.8445

RIG_SCORE: 0.8289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P311L	DO233731	GACA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.2222
p.P311L	DO233903	GACA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.2222
p.H318Q	DO228986	LICA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.7582
p.H318Q	DO229027	LICA	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.7582
p.Y306D	DO23240	LINC	ICGC	VRVHIE	LIG_APCC_ABBA_1	0.5278
p.I321S	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	VRVHIE	LIG_APCC_ABBA_1	0.3056
p.I321S	ACH-000562	Lung Cancer	CCLE	VRVHIE	LIG_APCC_ABBA_1	0.3056
p.I321S	HCC-78	lung	COSMIC	VRVHIE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P31943	Heterogeneous nuclear ribonucleoprotein H	LIG_APCC_ABBA_1	315:320	VRVHIE	APC,CDC20,FZR1	0.7541	More...
P52597	Heterogeneous nuclear ribonucleoprotein F	LIG_APCC_ABBA_1	315:320	VRVHIE	APC,CDC20,FZR1	0.7932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons