DegronMD

Uniprot ID: P52597

Source protein: Heterogeneous nuclear ribonucleoprotein F

Source gene: HNRNPF

Class: DEG_SPOP_SBC_1

Location: 283:287

E3 ligase: SPOP

DEGRON score: 0.7786

ASA_SCORE: 68.18

COIL: 0.833

CONS_SCORE: 0.3704

DSS_SCORE: 0.225

HELIX: 0.0622

FCONS_SCORE: 0.615

RIG_SCORE: 0.7535

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M293I	TCGA-18-3409	LUSC	TCGA	VQSTT	DEG_SPOP_SBC_1	0.1667
p.M293I	DO26444	LUSC	ICGC	VQSTT	DEG_SPOP_SBC_1	0.1667
p.R275K	TCGA-CV-7414	HNSC	TCGA	VQSTT	DEG_SPOP_SBC_1	0.1111
p.R275K	DO15631	HNSC	ICGC	VQSTT	DEG_SPOP_SBC_1	0.1111
p.H292Q	TCGA-OR-A5J7	ACC	TCGA	VQSTT	DEG_SPOP_SBC_1	0.1944
p.P297S	TCGA-QG-A5Z2	COAD	TCGA	VQSTT	DEG_SPOP_SBC_1	0.0556
p.P297S	DO44096	COAD	ICGC	VQSTT	DEG_SPOP_SBC_1	0.0556
p.E280K	DO223126	ESCA	ICGC	VQSTT	DEG_SPOP_SBC_1	0.25
p.G277S	DO232973	PEME	ICGC	VQSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P52597	Heterogeneous nuclear ribonucleoprotein F	DEG_SPOP_SBC_1	283:287	VQSTT	SPOP	0.7786	More...
Q9BQ04	RNA-binding protein 4B	DEG_SPOP_SBC_1	254:258	VQSTT	SPOP	0.9245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons