DegronMD

Uniprot ID: Q8N196

Source protein: Homeobox protein SIX5

Source gene: SIX5

Class: DEG_SIAH_1

Location: 423:431

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9618

ASA_SCORE: 67.0444

COIL: 0.7788

CONS_SCORE: 0.3969

DSS_SCORE: 0.4834

HELIX: 0.0228

FCONS_SCORE: 1.0095

RIG_SCORE: 0.7003

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A416V	TCGA-G4-6586	COAD	TCGA	GPLAQVVPG	DEG_SIAH_1	0.1389
p.A416V	DO9698	COAD	ICGC	GPLAQVVPG	DEG_SIAH_1	0.1389
p.G431A	TCGA-NH-A5IV	COAD	TCGA	GPLAQVVPG	DEG_SIAH_1	0.6429
p.G431A	DO49095	COAD	ICGC	GPLAQVVPG	DEG_SIAH_1	0.6429
p.E419D	DO234462	ESAD	ICGC	GPLAQVVPG	DEG_SIAH_1	0.2222
p.T434M	DO233671	GACA	ICGC	GPLAQVVPG	DEG_SIAH_1	0.25
p.P413S	SIDM00263	Ewing's Sarcoma	GDSC	GPLAQVVPG	DEG_SIAH_1	0.0556
p.P432S	ACH-000865	Esophageal Cancer	CCLE	GPLAQVVPG	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N196	Homeobox protein SIX5	DEG_SIAH_1	423:431	GPLAQVVPG	SIAH1,SIAH2,SIAH3	0.9618	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons