DegronMD - Q12965(MYO1E)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K883N	TCGA-28-5211	GBM	TCGA	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.K883N	DO11016	GBM	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.K882N	TCGA-AP-A1E0	UCEC	TCGA	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.5806
p.K882N	DO43154	UCEC	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.5806
p.N885D	TCGA-E1-A7Z3	LGG	TCGA	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6932
p.N885D	DO219805	LGG	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6932
p.E884G	DO233704	GACA	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.7199
p.T876K	DO229006	LICA	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation blocking phosphorylation signal	0.6111
p.P888A	DO231810	LINC	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.2778
p.R895W	DO48692	LIRI	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.R895L	DO231047	LUSC	ICGC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.T876R	SIDM00541	Colorectal Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation blocking phosphorylation signal	0.6111
p.T876R	SIDM00537	Colorectal Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation blocking phosphorylation signal	0.6111
p.T876R	SIDM01518	Oral Cavity Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	882:886	Mutation blocking phosphorylation signal	0.6111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons