DegronMD

Uniprot ID: Q12965

Source protein: Unconventional myosin-Ie

Source gene: MYO1E

Class: DEG_APCC_KENBOX_2

Location: 882:886

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7569

ASA_SCORE: 108.92

COIL: 0.4446

CONS_SCORE: 0.4727

DSS_SCORE: 0.3544

HELIX: 0.0456

FCONS_SCORE: 1.025

RIG_SCORE: 0.773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K883N	TCGA-28-5211	GBM	TCGA	KKENW	DEG_APCC_KENBOX_2	0.6918
p.K883N	DO11016	GBM	ICGC	KKENW	DEG_APCC_KENBOX_2	0.6918
p.K882N	TCGA-AP-A1E0	UCEC	TCGA	KKENW	DEG_APCC_KENBOX_2	0.5806
p.K882N	DO43154	UCEC	ICGC	KKENW	DEG_APCC_KENBOX_2	0.5806
p.N885D	TCGA-E1-A7Z3	LGG	TCGA	KKENW	DEG_APCC_KENBOX_2	0.6932
p.N885D	DO219805	LGG	ICGC	KKENW	DEG_APCC_KENBOX_2	0.6932
p.E884G	DO233704	GACA	ICGC	KKENW	DEG_APCC_KENBOX_2	0.7199
p.T876K	DO229006	LICA	ICGC	KKENW	DEG_APCC_KENBOX_2	0.6111
p.P888A	DO231810	LINC	ICGC	KKENW	DEG_APCC_KENBOX_2	0.2778
p.R895W	DO48692	LIRI	ICGC	KKENW	DEG_APCC_KENBOX_2	0.0833
p.R895L	DO231047	LUSC	ICGC	KKENW	DEG_APCC_KENBOX_2	0.0833
p.T876R	SIDM00541	Colorectal Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	0.6111
p.T876R	SIDM00537	Colorectal Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	0.6111
p.T876R	SIDM01518	Oral Cavity Carcinoma	GDSC	KKENW	DEG_APCC_KENBOX_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12965	Unconventional myosin-Ie	DEG_APCC_KENBOX_2	882:886	KKENW	APC,CDC20,FZR1	0.7569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons