DegronMD - Q8IUW3(SPATA2L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G364S	TCGA-55-8511	LUAD	TCGA	PPGY	ITCH	352:355	Mutation rewiring degron network	0.0833
p.G364S	DO24940	LUAD	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.0833
p.S344P	TCGA-AD-A5EJ	COAD	TCGA	PPGY	ITCH	352:355	Mutation rewiring degron network	0.1111
p.S344P	DO50090	COAD	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.1111
p.S350L	TCGA-AX-A2HA	UCEC	TCGA	PPGY	ITCH	352:355	Mutation rewiring degron network	0.2778
p.S350L	DO231141	LUSC	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.2778
p.S350L	DO42504	UCEC	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.2778
p.R313C	TCGA-B5-A3FC	UCEC	TCGA	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation rewiring degron network	0.0833
p.R313C	DO41871	UCEC	ICGC	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation rewiring degron network	0.0833
p.G354C	TCGA-D3-A3CE	SKCM	TCGA	PPGY	ITCH	352:355	Mutation altering degron motif	0.6489
p.G354C	DO37405	SKCM	ICGC	PPGY	ITCH	352:355	Mutation altering degron motif	0.6489
p.D226G	TCGA-EO-A22U	UCEC	TCGA	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6087
p.D226G	DO43755	UCEC	ICGC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6087
p.S359G	TCGA-FI-A2F4	UCEC	TCGA	PPGY	ITCH	352:355	Mutation rewiring degron network	0.2222
p.S359G	DO43434	UCEC	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.2222
p.L231F	TCGA-L9-A7SV	LUAD	TCGA	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.3056
p.L231F	DO49875	LUAD	ICGC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.3056
p.R314H	TCGA-VS-A9UJ	CESC	TCGA	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation rewiring degron network	0.1111
p.R314H	DO219735	CESC	ICGC	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation rewiring degron network	0.1111
p.A365T	DO10172	COAD	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.0556
p.A365T	DO222487	ESCA	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.0556
p.S362F	DO234230	ESAD	ICGC	PPGY	ITCH	352:355	Mutation rewiring degron network	0.1389
p.P224S	DO233088	GACA	ICGC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.3056
p.R229P	DO228241	LICA	ICGC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6401
p.R215P	DO219881	SKCA	ICGC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0556
p.A331T	DO231270	THCA	ICGC	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation rewiring degron network	0.25
p.Y355H	SIDM01169	Ovarian Carcinoma	GDSC	PPGY	ITCH	352:355	Mutation altering degron motif	0.7229
p.Y355H	ACH-000885	Ovarian Cancer	CCLE	PPGY	ITCH	352:355	Mutation altering degron motif	0.7229
p.R229Q	SIDM00789	Colorectal Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6218
p.R229Q	HCT-15	large intestine	COSMIC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.6218
p.G216S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.0833
p.A323V	SIDM00214	Colorectal Carcinoma	GDSC	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation altering degron motif	0.5825
p.A323V	ACH-000955	Colon/Colorectal Cancer	CCLE	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation altering degron motif	0.5825
p.A323V	SNU-407	large intestine	COSMIC	LATPESS	DEG_SCF_FBW7_1	322:328	Mutation altering degron motif	0.5825
p.R229L	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.7316
p.R229L	ACH-000886	Lung Cancer	CCLE	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.7316
p.R229L	NCI-H2009	lung	COSMIC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation altering degron motif	0.7316
p.A219T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1667
p.A219T	ACH-002222	Leukemia	CCLE	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1667
p.A219T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LDLYRD	LIG_APCC_ABBA_1	225:230	Mutation rewiring degron network	0.1667
p.Q356E	ACH-000791	Lung Cancer	CCLE	PPGY	ITCH	352:355	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPATA2L

UniProt ID: Q8IUW3

Entrez ID: 124044

Protein name: Spermatogenesis-associated protein 2-like protein (SPATA2-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPATA2L in