DegronMD

Uniprot ID: Q8IUW3

Source protein: Spermatogenesis-associated protein 2-like protein

Source gene: SPATA2L

Class: DEG_SCF_FBW7_1

Location: 322:328

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 74.5

COIL: 0.7873

CONS_SCORE: 0.6885

DSS_SCORE: 0.6067

HELIX: 0.1949

FCONS_SCORE: 1.1434

RIG_SCORE: 0.64

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R313C	TCGA-B5-A3FC	UCEC	TCGA	LATPESS	DEG_SCF_FBW7_1	0.0833
p.R313C	DO41871	UCEC	ICGC	LATPESS	DEG_SCF_FBW7_1	0.0833
p.R314H	TCGA-VS-A9UJ	CESC	TCGA	LATPESS	DEG_SCF_FBW7_1	0.1111
p.R314H	DO219735	CESC	ICGC	LATPESS	DEG_SCF_FBW7_1	0.1111
p.A331T	DO231270	THCA	ICGC	LATPESS	DEG_SCF_FBW7_1	0.25
p.A323V	SIDM00214	Colorectal Carcinoma	GDSC	LATPESS	DEG_SCF_FBW7_1	0.5825
p.A323V	ACH-000955	Colon/Colorectal Cancer	CCLE	LATPESS	DEG_SCF_FBW7_1	0.5825
p.A323V	SNU-407	large_intestine	COSMIC	LATPESS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUW3	Spermatogenesis-associated protein 2-like protein	DEG_SCF_FBW7_1	322:328	LATPESS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons