DegronMD

Uniprot ID: Q8IUW3

Source protein: Spermatogenesis-associated protein 2-like protein

Source gene: SPATA2L

Class: LIG_APCC_ABBA_1

Location: 225:230

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7182

ASA_SCORE: 91.6667

COIL: 0.7285

CONS_SCORE: 0.6664

DSS_SCORE: 0.6959

HELIX: 0.1993

FCONS_SCORE: 1.0593

RIG_SCORE: 0.7456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D226G	TCGA-EO-A22U	UCEC	TCGA	LDLYRD	LIG_APCC_ABBA_1	0.6087
p.D226G	DO43755	UCEC	ICGC	LDLYRD	LIG_APCC_ABBA_1	0.6087
p.L231F	TCGA-L9-A7SV	LUAD	TCGA	LDLYRD	LIG_APCC_ABBA_1	0.3056
p.L231F	DO49875	LUAD	ICGC	LDLYRD	LIG_APCC_ABBA_1	0.3056
p.P224S	DO233088	GACA	ICGC	LDLYRD	LIG_APCC_ABBA_1	0.3056
p.R229P	DO228241	LICA	ICGC	LDLYRD	LIG_APCC_ABBA_1	0.6401
p.R215P	DO219881	SKCA	ICGC	LDLYRD	LIG_APCC_ABBA_1	0.0556
p.R229Q	SIDM00789	Colorectal Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	0.6218
p.R229Q	HCT-15	large_intestine	COSMIC	LDLYRD	LIG_APCC_ABBA_1	0.6218
p.G216S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	0.0833
p.R229L	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	LDLYRD	LIG_APCC_ABBA_1	0.7316
p.R229L	ACH-000886	Lung Cancer	CCLE	LDLYRD	LIG_APCC_ABBA_1	0.7316
p.R229L	NCI-H2009	lung	COSMIC	LDLYRD	LIG_APCC_ABBA_1	0.7316
p.A219T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LDLYRD	LIG_APCC_ABBA_1	0.1667
p.A219T	ACH-002222	Leukemia	CCLE	LDLYRD	LIG_APCC_ABBA_1	0.1667
p.A219T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LDLYRD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IUW3	Spermatogenesis-associated protein 2-like protein	LIG_APCC_ABBA_1	225:230	LDLYRD	APC,CDC20,FZR1	0.7182	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons