DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PPGY
Uniprot ID:
Q9Y5P3
Source protein:
Retinoic acid-induced protein 2
Source gene:
RAI2
Class:
ITCH
Location:
206:209
E3 ligase:
ITCH,NEDD4
DEGRON score:
0.8504
ASA_SCORE:
83.025
COIL:
0.9553
CONS_SCORE:
0.5579
DSS_SCORE:
0.6204
HELIX:
0.0218
FCONS_SCORE:
0.8964
RIG_SCORE:
0.5536
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S208Y
NCI-H1993
lung
COSMIC
PPGY
ITCH
0.712
p.P206S
TCGA-B5-A0K4
UCEC
TCGA
PPGY
ITCH
0.6752
p.P206S
DO42360
UCEC
ICGC
PPGY
ITCH
0.6752
p.P207S
TCGA-EE-A2MF
SKCM
TCGA
PPGY
ITCH
0.6752
p.P207S
DO222491
MELA
ICGC
PPGY
ITCH
0.6752
p.P207S
DO51249
SKCM
ICGC
PPGY
ITCH
0.6752
p.A210T
TCGA-MA-AA42
CESC
TCGA
PPGY
ITCH
0.3056
p.A210T
DO219724
CESC
ICGC
PPGY
ITCH
0.3056
p.P214S
DO232224
PBCA
ICGC
PPGY
ITCH
0.1944
p.P214S
SIDM00760
Small Cell Lung Carcinoma
GDSC
PPGY
ITCH
0.1944
p.P214S
ACH-000729
Lung Cancer
CCLE
PPGY
ITCH
0.1944
p.P214S
NCI-H1963
lung
COSMIC
PPGY
ITCH
0.1944
p.G199W
TCGA-66-2734
LUSC
TCGA
PPGY
ITCH
0.1389
p.G199R
TCGA-BR-7723
STAD
TCGA
PPGY
ITCH
0.1389
p.G199E
TCGA-FW-A3R5
SKCM
TCGA
PPGY
ITCH
0.1389
p.G199E
DO37406
SKCM
ICGC
PPGY
ITCH
0.1389
Showing 1 to 16 of 16 entries
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Drug responses associated with RAI2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of PPGY
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95622
Adenylate cyclase type 5
ITCH
9:12
PPGY
ITCH,NEDD4
0.9301
More...
Q9BTX7
Alpha-tocopherol transfer protein-like
ITCH
28:31
PPGY
ITCH,NEDD4
0.9959
More...
O14497
AT-rich interactive domain-containing protein 1A
ITCH
912:915
PPGY
ITCH,NEDD4
0.9986
More...
P54259
Atrophin-1
ITCH
654:657
PPGY
ITCH,NEDD4
0.9979
More...
P54259
Atrophin-1
ITCH
670:673
PPGY
ITCH,NEDD4
0.9978
More...
Q9P281
BAH and coiled-coil domain-containing protein 1
ITCH
1088:1091
PPGY
ITCH,NEDD4
0.9811
More...
P98160
Basement membrane-specific heparan sulfate proteoglycan core protein
ITCH
1129:1132
PPGY
ITCH,NEDD4
0.621
More...
P11274
Breakpoint cluster region protein
ITCH
433:436
PPGY
ITCH,NEDD4
0.9994
More...
P27708
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase
ITCH
1802:1805
PPGY
ITCH,NEDD4
0.9935
More...
Q9H078
Caseinolytic peptidase B protein homolog
ITCH
427:430
PPGY
ITCH,NEDD4
0.978
More...
P49715
CCAAT/enhancer-binding protein alpha
ITCH
128:131
PPGY
ITCH,NEDD4
0.7286
More...
Q7Z7A1
Centriolin
ITCH
1241:1244
PPGY
ITCH,NEDD4
0.5834
More...
Q12873
Chromodomain-helicase-DNA-binding protein 3
ITCH
1928:1931
PPGY
ITCH,NEDD4
0.7534
More...
P02462
Collagen alpha-1
ITCH
605:608
PPGY
ITCH,NEDD4
0.6191
More...
Q07092
Collagen alpha-1
ITCH
1542:1545
PPGY
ITCH,NEDD4
0.9879
More...
Q2UY09
Collagen alpha-1
ITCH
703:706
PPGY
ITCH,NEDD4
0.9911
More...
Q99715
Collagen alpha-1
ITCH
3040:3043
PPGY
ITCH,NEDD4
0.9593
More...
Q14055
Collagen alpha-2
ITCH
563:566
PPGY
ITCH,NEDD4
0.9513
More...
P25940
Collagen alpha-3
ITCH
705:708
PPGY
ITCH,NEDD4
0.9233
More...
Q01955
Collagen alpha-3
ITCH
615:618
PPGY
ITCH,NEDD4
0.605
More...
Q14050
Collagen alpha-3
ITCH
579:582
PPGY
ITCH,NEDD4
0.7798
More...
P53420
Collagen alpha-4
ITCH
1308:1311
PPGY
ITCH,NEDD4
0.6498
More...
Q5VXM1
CUB domain-containing protein 2
ITCH
290:293
PPGY
ITCH,NEDD4
0.707
More...
Q5JSL3
Dedicator of cytokinesis protein 11
ITCH
782:785
PPGY
ITCH,NEDD4
0.5608
More...
Q92796
Disks large homolog 3
ITCH
27:30
PPGY
ITCH,NEDD4
0.8861
More...
Showing 1 to 25 of 106 entries
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