DegronMD - Q12873(CHD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1555F	TCGA-06-5416	GBM	TCGA	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation altering degron motif	0.7982
p.R335Q	TCGA-A5-A1OF	UCEC	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation blocking phosphorylation signal	0.7222
p.R335Q	TCGA-CG-5718	STAD	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation blocking phosphorylation signal	0.7222
p.G1529S	TCGA-A5-A1OF	UCEC	TCGA	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.0556
p.D338H	TCGA-A8-A0AB	BRCA	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1944
p.R1570C	TCGA-AJ-A3EK	UCEC	TCGA	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0833
p.R1570C	TCGA-BS-A0UM	UCEC	TCGA	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0833
p.R1570C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0833
p.R1570C	ACH-001127	Leukemia	CCLE	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0833
p.R1570C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0833
p.V1923A	TCGA-AZ-6601	COAD	TCGA	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.G326D	TCGA-B5-A11E	UCEC	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.3056
p.D1535N	TCGA-BH-A2L8	BRCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation blocking phosphorylation signal	0.6667
p.R1940C	TCGA-BR-8382	STAD	TCGA	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.0833
p.P1538R	TCGA-E7-A6ME	BLCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.3056
p.A1936V	TCGA-GC-A4ZW	BLCA	TCGA	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	SIDM00217	Colorectal Carcinoma	GDSC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	ACH-000980	Lung Cancer	CCLE	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	ACH-000999	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	SNU-1040	large intestine	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.A1936V	NCI-H1155	lung	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1944
p.R1544H	TCGA-LN-A49X	ESCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation altering degron motif	0.8244
p.L1571V	DO48579	BLCA	ICGC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.0556
p.R343C	DO233270	GACA	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.0556
p.R343C	DO42600	UCEC	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.0556
p.S1533P	DO16101	HNSC	ICGC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation blocking phosphorylation signal	0.6111
p.G1922V	DO228948	LICA	ICGC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1667
p.L1935F	DO45299	LIRI	ICGC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.2222
p.G340C	DO23711	LUAD	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1389
p.E320K	DO45384	LUAD	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1389
p.P1550L	DO222615	MELA	ICGC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.1944
p.P1550L	DO222615	MELA	ICGC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1944
p.P1550L	DO38177	SKCM	ICGC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.1944
p.P1550L	DO38177	SKCM	ICGC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1944
p.R1530T	DO222843	MELA	ICGC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.0833
p.T1557S	DO220042	SARC	ICGC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation altering degron motif	0.8227
p.A1928T	DO41014	UCEC	ICGC	PPGY	ITCH	1928:1931	Mutation altering degron motif	0.7139
p.T1537M	DO223286	UCEC	ICGC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation blocking phosphorylation signal	0.7222
p.R1940H	SIDM02026	Colorectal Carcinoma	GDSC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.0833
p.N1568D	SIDM00281	Other Solid Cancers	GDSC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1389
p.N1568D	ACH-002100	Skin Cancer	CCLE	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1389
p.N1568D	DJM-1	skin	COSMIC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1389
p.D338N	SIDM00923	Cervical Carcinoma	GDSC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1944
p.D338N	ACH-001336	Cervical Cancer	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1944
p.D338N	Ca-Ski	cervix	COSMIC	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1944
p.I1567V	SIDM00683	Prostate Carcinoma	GDSC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1667
p.I1567V	LNCaP-Clone-FGC	prostate	COSMIC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1667
p.R1550C	SIDM00487	Colorectal Carcinoma	GDSC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.1944
p.R1550C	SIDM00487	Colorectal Carcinoma	GDSC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1944
p.R1550C	ACH-000963	Colon/Colorectal Cancer	CCLE	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.1944
p.R1550C	ACH-000963	Colon/Colorectal Cancer	CCLE	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1944
p.R1550C	CCK-81	large intestine	COSMIC	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation rewiring degron network	0.1944
p.R1550C	CCK-81	large intestine	COSMIC	PATPAPS	DEG_SCF_FBW7_1	1555:1561	Mutation rewiring degron network	0.1944
p.K341T	ACH-000612	Lymphoma	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1111
p.K341T	ACH-001992	Primary	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	327:333	Mutation rewiring degron network	0.1111
p.E1540A	ACH-001063	Ovarian Cancer	CCLE	PTTPEAS	DEG_SCF_FBW7_1	1539:1545	Mutation altering degron motif	0.7701
p.K1940N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.0833
p.P1921L	CAL-72	bone	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1389
p.P1929L	NUGC-3	stomach	COSMIC	PPGY	ITCH	1928:1931	Mutation altering degron motif	0.7582
p.P1922L	LoVo	large intestine	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.1667
p.P1933L	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	1928:1931	Mutation rewiring degron network	0.2778

Kaplan plot for CHD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD3

UniProt ID: Q12873

Entrez ID: 1107

Protein name: Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.12) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD3 in