DegronMD

Uniprot ID: Q12873

Source protein: Chromodomain-helicase-DNA-binding protein 3

Source gene: CHD3

Class: DEG_SCF_TRCP1_1

Location: 327:333

E3 ligase: BTRC

DEGRON score: 0.8384

ASA_SCORE: 82.5714

COIL: 0.8649

CONS_SCORE: 0.2339

DSS_SCORE: 0.7456

HELIX: 0.1049

FCONS_SCORE: 0.9775

RIG_SCORE: 0.567

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R335Q	TCGA-A5-A1OF	UCEC	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	0.7222
p.R335Q	TCGA-CG-5718	STAD	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	0.7222
p.D338H	TCGA-A8-A0AB	BRCA	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	0.1944
p.G326D	TCGA-B5-A11E	UCEC	TCGA	DSGSVHS	DEG_SCF_TRCP1_1	0.3056
p.R343C	DO233270	GACA	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	0.0556
p.R343C	DO42600	UCEC	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	0.0556
p.G340C	DO23711	LUAD	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	0.1389
p.E320K	DO45384	LUAD	ICGC	DSGSVHS	DEG_SCF_TRCP1_1	0.1389
p.D338N	SIDM00923	Cervical Carcinoma	GDSC	DSGSVHS	DEG_SCF_TRCP1_1	0.1944
p.D338N	ACH-001336	Cervical Cancer	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	0.1944
p.D338N	Ca-Ski	cervix	COSMIC	DSGSVHS	DEG_SCF_TRCP1_1	0.1944
p.K341T	ACH-000612	Lymphoma	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	0.1111
p.K341T	ACH-001992	Primary	CCLE	DSGSVHS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12873	Chromodomain-helicase-DNA-binding protein 3	DEG_SCF_TRCP1_1	327:333	DSGSVHS	BTRC	0.8384	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons