DegronMD

Uniprot ID: Q12873

Source protein: Chromodomain-helicase-DNA-binding protein 3

Source gene: CHD3

Class: DEG_SCF_FBW7_1

Location: 1539:1545

E3 ligase: FBXW7

DEGRON score: 0.9988

ASA_SCORE: 81.0143

COIL: 0.8437

CONS_SCORE: 0.2543

DSS_SCORE: 0.7312

HELIX: 0.1237

FCONS_SCORE: 1.0442

RIG_SCORE: 0.5448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1529S	TCGA-A5-A1OF	UCEC	TCGA	PTTPEAS	DEG_SCF_FBW7_1	0.0556
p.D1535N	TCGA-BH-A2L8	BRCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	0.6667
p.P1538R	TCGA-E7-A6ME	BLCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	0.3056
p.R1544H	TCGA-LN-A49X	ESCA	TCGA	PTTPEAS	DEG_SCF_FBW7_1	0.8244
p.S1533P	DO16101	HNSC	ICGC	PTTPEAS	DEG_SCF_FBW7_1	0.6111
p.P1550L	DO222615	MELA	ICGC	PTTPEAS	DEG_SCF_FBW7_1	0.1944
p.P1550L	DO38177	SKCM	ICGC	PTTPEAS	DEG_SCF_FBW7_1	0.1944
p.R1530T	DO222843	MELA	ICGC	PTTPEAS	DEG_SCF_FBW7_1	0.0833
p.T1537M	DO223286	UCEC	ICGC	PTTPEAS	DEG_SCF_FBW7_1	0.7222
p.R1550C	SIDM00487	Colorectal Carcinoma	GDSC	PTTPEAS	DEG_SCF_FBW7_1	0.1944
p.R1550C	ACH-000963	Colon/Colorectal Cancer	CCLE	PTTPEAS	DEG_SCF_FBW7_1	0.1944
p.R1550C	CCK-81	large_intestine	COSMIC	PTTPEAS	DEG_SCF_FBW7_1	0.1944
p.E1540A	ACH-001063	Ovarian Cancer	CCLE	PTTPEAS	DEG_SCF_FBW7_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12873	Chromodomain-helicase-DNA-binding protein 3	DEG_SCF_FBW7_1	1539:1545	PTTPEAS	FBXW7	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons