DegronMD

Uniprot ID: Q12873

Source protein: Chromodomain-helicase-DNA-binding protein 3

Source gene: CHD3

Class: DEG_SCF_FBW7_1

Location: 1555:1561

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 72.8429

COIL: 0.9197

CONS_SCORE: 0.25

DSS_SCORE: 0.7441

HELIX: 0.0321

FCONS_SCORE: 1.0754

RIG_SCORE: 0.5541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1555F	TCGA-06-5416	GBM	TCGA	PATPAPS	DEG_SCF_FBW7_1	0.7982
p.R1570C	TCGA-AJ-A3EK	UCEC	TCGA	PATPAPS	DEG_SCF_FBW7_1	0.0833
p.R1570C	TCGA-BS-A0UM	UCEC	TCGA	PATPAPS	DEG_SCF_FBW7_1	0.0833
p.R1570C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PATPAPS	DEG_SCF_FBW7_1	0.0833
p.R1570C	ACH-001127	Leukemia	CCLE	PATPAPS	DEG_SCF_FBW7_1	0.0833
p.R1570C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PATPAPS	DEG_SCF_FBW7_1	0.0833
p.L1571V	DO48579	BLCA	ICGC	PATPAPS	DEG_SCF_FBW7_1	0.0556
p.P1550L	DO222615	MELA	ICGC	PATPAPS	DEG_SCF_FBW7_1	0.1944
p.P1550L	DO38177	SKCM	ICGC	PATPAPS	DEG_SCF_FBW7_1	0.1944
p.T1557S	DO220042	SARC	ICGC	PATPAPS	DEG_SCF_FBW7_1	0.8227
p.N1568D	SIDM00281	Other Solid Cancers	GDSC	PATPAPS	DEG_SCF_FBW7_1	0.1389
p.N1568D	ACH-002100	Skin Cancer	CCLE	PATPAPS	DEG_SCF_FBW7_1	0.1389
p.N1568D	DJM-1	skin	COSMIC	PATPAPS	DEG_SCF_FBW7_1	0.1389
p.I1567V	SIDM00683	Prostate Carcinoma	GDSC	PATPAPS	DEG_SCF_FBW7_1	0.1667
p.I1567V	LNCaP-Clone-FGC	prostate	COSMIC	PATPAPS	DEG_SCF_FBW7_1	0.1667
p.R1550C	SIDM00487	Colorectal Carcinoma	GDSC	PATPAPS	DEG_SCF_FBW7_1	0.1944
p.R1550C	ACH-000963	Colon/Colorectal Cancer	CCLE	PATPAPS	DEG_SCF_FBW7_1	0.1944
p.R1550C	CCK-81	large_intestine	COSMIC	PATPAPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12873	Chromodomain-helicase-DNA-binding protein 3	DEG_SCF_FBW7_1	1555:1561	PATPAPS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons