DegronMD - P27708(CAD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L1881P	TCGA-AX-A0J0	UCEC	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation altering degron motif	0.6471
p.G1883R	TCGA-B5-A11E	UCEC	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation altering degron motif	0.6457
p.G1797W	TCGA-DA-A1I7	SKCM	TCGA	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.1944
p.L1800P	TCGA-DI-A1BU	UCEC	TCGA	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2778
p.G1887C	TCGA-G4-6320	COAD	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation altering degron motif	0.6489
p.R1874Q	TCGA-W3-AA1V	SKCM	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1389
p.E1803K	DO514	BLCA	ICGC	PPGY	ITCH	1802:1805	Mutation altering degron motif	0.7022
p.R1892W	DO5088	BRCA	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.2222
p.R1885C	DO8858	COAD	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation altering degron motif	0.8301
p.R1885C	DO42608	UCEC	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation altering degron motif	0.8301
p.E1891K	DO229177	LMS	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.25
p.R1811Q	DO51276	SKCM	ICGC	PPGY	ITCH	1802:1805	Mutation substituting flanking lysine	0.2778
p.S1893G	DO42673	UCEC	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1944
p.V1809I	SIDM01948	Pancreatic Carcinoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.V1895I	SIDM00491	Thyroid Gland Carcinoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1389
p.V1895I	SIDM00544	Neuroblastoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1389
p.V1895I	GOTO	autonomic ganglia	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1389
p.V1895I	ASH-3	thyroid	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1389
p.Q1798K	SIDM00202	Ewing's Sarcoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.Q1798K	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.Q1798K	SIDM00472	Ovarian Carcinoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.Q1798K	SIDM00685	Glioblastoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.Q1798K	SIDM01012	Other Blood Cancers	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.Y1890C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation blocking phosphorylation signal	0.7222
p.Y1890C	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation blocking phosphorylation signal	0.7222
p.P1891H	SIDM00282	Colorectal Carcinoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.25
p.P1891H	CW-2	large intestine	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.25
p.D1808G	SIDM00333	Endometrial Carcinoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.25
p.D1808G	MFE-319	endometrium	COSMIC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.25
p.V1809A	SIDM00217	Colorectal Carcinoma	GDSC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.V1809A	SNU-1040	large intestine	COSMIC	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.2222
p.I1792M	ACH-000592	Brain Cancer	CCLE	PPGY	ITCH	1802:1805	Mutation rewiring degron network	0.0556
p.E1804D	ACH-000871	Lung Cancer	CCLE	PPGY	ITCH	1802:1805	Mutation altering degron motif	0.6758
p.E1804D	NCI-H510A	lung	COSMIC	PPGY	ITCH	1802:1805	Mutation altering degron motif	0.6758
p.P1896S	Sarc9371	bone	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	1881:1888	Mutation rewiring degron network	0.1111

Kaplan plot for CAD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CAD

UniProt ID: P27708

Entrez ID: 790

Protein name: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CAD in