DegronMD

Uniprot ID: P27708

Source protein: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase

Source gene: CAD

Class: DEG_SCF_FBW7_1

Location: 1881:1888

E3 ligase: FBXW7

DEGRON score: 0.9985

ASA_SCORE: 73.1875

COIL: 0.8779

CONS_SCORE: 0.2019

DSS_SCORE: 0.702

HELIX: 0.0864

FCONS_SCORE: 1.0398

RIG_SCORE: 0.5827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1881P	TCGA-AX-A0J0	UCEC	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	0.6471
p.G1883R	TCGA-B5-A11E	UCEC	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	0.6457
p.G1887C	TCGA-G4-6320	COAD	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	0.6489
p.R1874Q	TCGA-W3-AA1V	SKCM	TCGA	LMGTPDGT	DEG_SCF_FBW7_1	0.1389
p.R1892W	DO5088	BRCA	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	0.2222
p.R1885C	DO8858	COAD	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	0.8301
p.R1885C	DO42608	UCEC	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	0.8301
p.E1891K	DO229177	LMS	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	0.25
p.S1893G	DO42673	UCEC	ICGC	LMGTPDGT	DEG_SCF_FBW7_1	0.1944
p.V1895I	SIDM00491	Thyroid Gland Carcinoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	0.1389
p.V1895I	SIDM00544	Neuroblastoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	0.1389
p.V1895I	GOTO	autonomic_ganglia	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	0.1389
p.V1895I	ASH-3	thyroid	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	0.1389
p.Y1890C	SIDM00364	B-Lymphoblastic Leukemia	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	0.7222
p.Y1890C	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	0.7222
p.P1891H	SIDM00282	Colorectal Carcinoma	GDSC	LMGTPDGT	DEG_SCF_FBW7_1	0.25
p.P1891H	CW-2	large_intestine	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	0.25
p.P1896S	Sarc9371	bone	COSMIC	LMGTPDGT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P27708	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	DEG_SCF_FBW7_1	1881:1888	LMGTPDGT	FBXW7	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons