DegronMD

Uniprot ID: O95967

Source protein: EGF-containing fibulin-like extracellular matrix protein 2

Source gene: EFEMP2

Class: ITCH

Location: 110:113

E3 ligase: ITCH,NEDD4

DEGRON score: 0.8013

ASA_SCORE: 66.225

COIL: 0.8093

CONS_SCORE: 0.742

DSS_SCORE: 0.6442

HELIX: 0.0195

FCONS_SCORE: 1.2939

RIG_SCORE: 0.5274

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P110L	DO229031	LICA	ICGC	PPGY	ITCH	0.7582
p.P110A	SIDM00214	Colorectal Carcinoma	GDSC	PPGY	ITCH	0.7503
p.P110A	ACH-000955	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	0.7503
p.P110A	SNU-407	large_intestine	COSMIC	PPGY	ITCH	0.7503
p.G112D	TCGA-A5-A2K5	UCEC	TCGA	PPGY	ITCH	0.6087
p.G112D	DO41379	UCEC	ICGC	PPGY	ITCH	0.6087
p.E114D	TCGA-DU-7294	LGG	TCGA	PPGY	ITCH	0.3056
p.E114D	DO22333	LGG	ICGC	PPGY	ITCH	0.3056
p.P115A	TCGA-17-Z031	LUAD	TCGA	PPGY	ITCH	0.2778
p.D116E	DO229018	LICA	ICGC	PPGY	ITCH	0.25
p.A103T	TCGA-CV-5441	HNSC	TCGA	PPGY	ITCH	0.1389
p.A103T	DO15671	HNSC	ICGC	PPGY	ITCH	0.1389
p.A103T	SIDM00683	Prostate Carcinoma	GDSC	PPGY	ITCH	0.1389
p.A103T	ACH-000977	lymph_node	CCLE	PPGY	ITCH	0.1389
p.A103T	LNCaP-Clone-FGC	prostate	COSMIC	PPGY	ITCH	0.1389
p.A103V	SIDM00945	Colorectal Carcinoma	GDSC	PPGY	ITCH	0.1389
p.A103V	ACH-000895	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	0.1389
p.A103V	CL-34	large_intestine	COSMIC	PPGY	ITCH	0.1389
p.P101L	TCGA-D3-A8GI	SKCM	TCGA	PPGY	ITCH	0.0833
p.P101L	DO50284	SKCM	ICGC	PPGY	ITCH	0.0833
p.P101T	DO229031	LICA	ICGC	PPGY	ITCH	0.0833
p.D123Y	TCGA-EP-A12J	LIHC	TCGA	PPGY	ITCH	0.0556
p.D123Y	DO22950	LIHC	ICGC	PPGY	ITCH	0.0556
p.D123H	TCGA-EQ-A4SO	STAD	TCGA	PPGY	ITCH	0.0556
p.D123H	DO47893	STAD	ICGC	PPGY	ITCH	0.0556

Showing 1 to 25 of 25 entries

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Drug responses associated with EFEMP2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPGY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95622	Adenylate cyclase type 5	ITCH	9:12	PPGY	ITCH,NEDD4	0.9301	More...
Q9BTX7	Alpha-tocopherol transfer protein-like	ITCH	28:31	PPGY	ITCH,NEDD4	0.9959	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	912:915	PPGY	ITCH,NEDD4	0.9986	More...
P54259	Atrophin-1	ITCH	654:657	PPGY	ITCH,NEDD4	0.9979	More...
P54259	Atrophin-1	ITCH	670:673	PPGY	ITCH,NEDD4	0.9978	More...
Q9P281	BAH and coiled-coil domain-containing protein 1	ITCH	1088:1091	PPGY	ITCH,NEDD4	0.9811	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	ITCH	1129:1132	PPGY	ITCH,NEDD4	0.621	More...
P11274	Breakpoint cluster region protein	ITCH	433:436	PPGY	ITCH,NEDD4	0.9994	More...
P27708	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	ITCH	1802:1805	PPGY	ITCH,NEDD4	0.9935	More...
Q9H078	Caseinolytic peptidase B protein homolog	ITCH	427:430	PPGY	ITCH,NEDD4	0.978	More...
P49715	CCAAT/enhancer-binding protein alpha	ITCH	128:131	PPGY	ITCH,NEDD4	0.7286	More...
Q7Z7A1	Centriolin	ITCH	1241:1244	PPGY	ITCH,NEDD4	0.5834	More...
Q12873	Chromodomain-helicase-DNA-binding protein 3	ITCH	1928:1931	PPGY	ITCH,NEDD4	0.7534	More...
P02462	Collagen alpha-1	ITCH	605:608	PPGY	ITCH,NEDD4	0.6191	More...
Q07092	Collagen alpha-1	ITCH	1542:1545	PPGY	ITCH,NEDD4	0.9879	More...
Q2UY09	Collagen alpha-1	ITCH	703:706	PPGY	ITCH,NEDD4	0.9911	More...
Q99715	Collagen alpha-1	ITCH	3040:3043	PPGY	ITCH,NEDD4	0.9593	More...
Q14055	Collagen alpha-2	ITCH	563:566	PPGY	ITCH,NEDD4	0.9513	More...
P25940	Collagen alpha-3	ITCH	705:708	PPGY	ITCH,NEDD4	0.9233	More...
Q01955	Collagen alpha-3	ITCH	615:618	PPGY	ITCH,NEDD4	0.605	More...
Q14050	Collagen alpha-3	ITCH	579:582	PPGY	ITCH,NEDD4	0.7798	More...
P53420	Collagen alpha-4	ITCH	1308:1311	PPGY	ITCH,NEDD4	0.6498	More...
Q5VXM1	CUB domain-containing protein 2	ITCH	290:293	PPGY	ITCH,NEDD4	0.707	More...
Q5JSL3	Dedicator of cytokinesis protein 11	ITCH	782:785	PPGY	ITCH,NEDD4	0.5608	More...
Q92796	Disks large homolog 3	ITCH	27:30	PPGY	ITCH,NEDD4	0.8861	More...

Showing 1 to 25 of 106 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPGY

Degron related mutations and impact score

Drug responses associated with EFEMP2 mutations

All proteins holding degron of PPGY