DegronMD - P36915(GNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L83V	TCGA-04-1369	OV	TCGA	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation altering degron motif	0.5654
p.L83V	DO28183	OV	ICGC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation altering degron motif	0.5654
p.R90K	TCGA-50-6597	LUAD	TCGA	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation rewiring degron network	0.2222
p.R90K	DO26062	LUAD	ICGC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation rewiring degron network	0.2222
p.S524I	TCGA-86-8279	LUAD	TCGA	PPGY	ITCH	520:523	Mutation rewiring degron network	0.3056
p.S524I	DO24140	LUAD	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.3056
p.S532F	TCGA-BR-8487	STAD	TCGA	PPGY	ITCH	520:523	Mutation rewiring degron network	0.0833
p.S532F	DO47867	STAD	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.0833
p.H533Y	TCGA-DU-8167	LGG	TCGA	PPGY	ITCH	520:523	Mutation rewiring degron network	0.0556
p.H533Y	DO22608	LGG	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.0556
p.R513C	TCGA-EO-A22T	UCEC	TCGA	PPGY	ITCH	520:523	Mutation rewiring degron network	0.1389
p.R513C	DO42320	UCEC	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.1389
p.V510G	DO48413	BLCA	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.0556
p.W530R	DO229188	THCA	ICGC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.1389
p.S524G	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.3056
p.S524G	ACH-000914	Lymphoma	CCLE	PPGY	ITCH	520:523	Mutation rewiring degron network	0.3056
p.S524G	HT	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	520:523	Mutation rewiring degron network	0.3056
p.Y81H	SIDM01045	Endometrial Carcinoma	GDSC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation altering degron motif	0.7229
p.Y81H	EN	endometrium	COSMIC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	80:86	Mutation altering degron motif	0.7229

Kaplan plot for GNL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GNL1

UniProt ID: P36915

Entrez ID: 2794

Protein name: Guanine nucleotide-binding protein-like 1 (GTP-binding protein HSR1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GNL1 in