DegronMD

Uniprot ID: P36915

Source protein: Guanine nucleotide-binding protein-like 1

Source gene: GNL1

Class: LIG_APCC_ABBAyCdc20_2

Location: 80:86

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8268

ASA_SCORE: 64.9429

COIL: 0.3046

CONS_SCORE: 0.4094

DSS_SCORE: 0.5463

HELIX: 0.1099

FCONS_SCORE: 1.1072

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L83V	TCGA-04-1369	OV	TCGA	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.5654
p.L83V	DO28183	OV	ICGC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.5654
p.R90K	TCGA-50-6597	LUAD	TCGA	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R90K	DO26062	LUAD	ICGC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.2222
p.Y81H	SIDM01045	Endometrial Carcinoma	GDSC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.7229
p.Y81H	EN	endometrium	COSMIC	RYRLHFE	LIG_APCC_ABBAyCdc20_2	0.7229

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36915	Guanine nucleotide-binding protein-like 1	LIG_APCC_ABBAyCdc20_2	80:86	RYRLHFE	APC,CDC20,FZR1	0.8268	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons