DegronMD - O95967(EFEMP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P115A	TCGA-17-Z031	LUAD	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.2778
p.G112D	TCGA-A5-A2K5	UCEC	TCGA	PPGY	ITCH	110:113	Mutation altering degron motif	0.6087
p.G112D	DO41379	UCEC	ICGC	PPGY	ITCH	110:113	Mutation altering degron motif	0.6087
p.A103T	TCGA-CV-5441	HNSC	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103T	DO15671	HNSC	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103T	SIDM00683	Prostate Carcinoma	GDSC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103T	ACH-000977	lymph node	CCLE	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103T	LNCaP-Clone-FGC	prostate	COSMIC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.P101L	TCGA-D3-A8GI	SKCM	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0833
p.P101L	DO50284	SKCM	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0833
p.E114D	TCGA-DU-7294	LGG	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.3056
p.E114D	DO22333	LGG	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.3056
p.D123Y	TCGA-EP-A12J	LIHC	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0556
p.D123Y	DO22950	LIHC	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0556
p.D123H	TCGA-EQ-A4SO	STAD	TCGA	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0556
p.D123H	DO47893	STAD	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0556
p.D116E	DO229018	LICA	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.25
p.P101T	DO229031	LICA	ICGC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.0833
p.P110L	DO229031	LICA	ICGC	PPGY	ITCH	110:113	Mutation altering degron motif	0.7582
p.A103V	SIDM00945	Colorectal Carcinoma	GDSC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103V	ACH-000895	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.A103V	CL-34	large intestine	COSMIC	PPGY	ITCH	110:113	Mutation rewiring degron network	0.1389
p.P110A	SIDM00214	Colorectal Carcinoma	GDSC	PPGY	ITCH	110:113	Mutation altering degron motif	0.7503
p.P110A	ACH-000955	Colon/Colorectal Cancer	CCLE	PPGY	ITCH	110:113	Mutation altering degron motif	0.7503
p.P110A	SNU-407	large intestine	COSMIC	PPGY	ITCH	110:113	Mutation altering degron motif	0.7503

Kaplan plot for EFEMP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFEMP2

UniProt ID: O95967

Entrez ID: 30008

Protein name: EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFEMP2 in