DegronMD - Q9NRR4(DROSHA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y168H	TCGA-AA-3672	COAD	TCGA	PPGY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.Y168H	DO9010	COAD	ICGC	PPGY	ITCH	169:172	Mutation rewiring degron network	0.3056
p.P180S	TCGA-AP-A1DK	UCEC	TCGA	PPGY	ITCH	169:172	Mutation rewiring degron network	0.1111
p.P180S	DO42033	UCEC	ICGC	PPGY	ITCH	169:172	Mutation rewiring degron network	0.1111
p.D671Y	TCGA-AP-A1DV	UCEC	TCGA	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.7325
p.D671Y	DO43186	UCEC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.7325
p.F182S	TCGA-B6-A0IJ	BRCA	TCGA	PPGY	ITCH	169:172	Mutation rewiring degron network	0.0556
p.F182S	DO2813	BRCA	ICGC	PPGY	ITCH	169:172	Mutation rewiring degron network	0.0556
p.D655Y	TCGA-E6-A1LX	UCEC	TCGA	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.0556
p.D655Y	DO41020	UCEC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.0556
p.P55L	TCGA-EE-A2MS	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.P55L	DO37567	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.P169R	TCGA-WE-A8ZM	SKCM	TCGA	PPGY	ITCH	169:172	Mutation altering degron motif	0.7512
p.P169R	DO51284	SKCM	ICGC	PPGY	ITCH	169:172	Mutation altering degron motif	0.7512
p.L666V	DO474	BLCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6765
p.L666V	DO24850	LUAD	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6765
p.L668F	DO224685	COCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6981
p.L668F	DO224731	COCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.6981
p.F63V	DO233703	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.3056
p.V677L	DO52208	LIHC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1667
p.N70S	DO231040	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1111
p.L667M	DO51236	SKCM	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation altering degron motif	0.711
p.V49M	DO229213	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.P56S	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P56S	SIDM00455	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P56S	SIDM00453	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P56S	SIDM01055	Glioblastoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P56S	SIDM00889	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P56S	SIDM01750	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.2778
p.P67T	SIDM00672	Hepatocellular Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM00846	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM00650	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM00694	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM00068	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM01681	Non-Cancerous	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.P67T	SIDM01409	Bladder Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.S672N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.3056
p.S672N	ACH-002275	Leukemia	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.3056
p.L657F	ACH-000816	Lung Cancer	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1111
p.L657F	NCI-H524	lung	COSMIC	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1111
p.R678K	ACH-001719	Ovarian Cancer	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	665:671	Mutation rewiring degron network	0.1389

Kaplan plot for DROSHA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DROSHA

UniProt ID: Q9NRR4

Entrez ID: 29102

Protein name: Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DROSHA in