DegronMD

Uniprot ID: Q9NRR4

Source protein: Ribonuclease 3

Source gene: DROSHA

Class: LIG_APCC_ABBAyCdc20_2

Location: 665:671

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7953

ASA_SCORE: 78.9857

COIL: 0.8704

CONS_SCORE: 0.3427

DSS_SCORE: 0.066

HELIX: 0.078

FCONS_SCORE: 0.6868

RIG_SCORE: 0.8102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D671Y	TCGA-AP-A1DV	UCEC	TCGA	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.7325
p.D671Y	DO43186	UCEC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.7325
p.D655Y	TCGA-E6-A1LX	UCEC	TCGA	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.D655Y	DO41020	UCEC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.L666V	DO474	BLCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.6765
p.L666V	DO24850	LUAD	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.6765
p.L668F	DO224685	COCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.6981
p.L668F	DO224731	COCA	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.6981
p.V677L	DO52208	LIHC	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.L667M	DO51236	SKCM	ICGC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.711
p.S672N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S672N	ACH-002275	Leukemia	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.L657F	ACH-000816	Lung Cancer	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.L657F	NCI-H524	lung	COSMIC	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.R678K	ACH-001719	Ovarian Cancer	CCLE	KGPLFED	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRR4	Ribonuclease 3	LIG_APCC_ABBAyCdc20_2	665:671	KGPLFED	APC,CDC20,FZR1	0.7953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons