DegronMD

Uniprot ID: Q9NRR4

Source protein: Ribonuclease 3

Source gene: DROSHA

Class: DEG_SPOP_SBC_1

Location: 58:62

E3 ligase: SPOP

DEGRON score: 0.9364

ASA_SCORE: 62.12

COIL: 0.9086

CONS_SCORE: 0.3318

DSS_SCORE: 0.6725

HELIX: 0.0568

FCONS_SCORE: 0.9647

RIG_SCORE: 0.5636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P55L	TCGA-EE-A2MS	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	0.25
p.P55L	DO37567	SKCM	ICGC	APSTT	DEG_SPOP_SBC_1	0.25
p.F63V	DO233703	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	0.3056
p.N70S	DO231040	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.1111
p.V49M	DO229213	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.0833
p.P56S	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P56S	SIDM00455	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P56S	SIDM00453	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P56S	SIDM01055	Glioblastoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P56S	SIDM00889	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P56S	SIDM01750	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.2778
p.P67T	SIDM00672	Hepatocellular Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM00846	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM00650	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM00694	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM00068	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM01681	Non-Cancerous	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944
p.P67T	SIDM01409	Bladder Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	140:144	APSTT	SPOP	0.8845	More...
O15389	Sialic acid-binding Ig-like lectin 5	DEG_SPOP_SBC_1	538:542	APSTT	SPOP	0.9802	More...
O43150	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	778:782	APSTT	SPOP	0.8384	More...
P49765	Vascular endothelial growth factor B	DEG_SPOP_SBC_1	179:183	APSTT	SPOP	0.9197	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	295:299	APSTT	SPOP	0.9983	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1332:1336	APSTT	SPOP	0.9016	More...
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_SPOP_SBC_1	335:339	APSTT	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6958:6962	APSTT	SPOP	0.9902	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7577:7581	APSTT	SPOP	0.9928	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	3488:3492	APSTT	SPOP	0.8928	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9773	More...
Q96M61	Melanoma-associated antigen B18	DEG_SPOP_SBC_1	67:71	APSTT	SPOP	0.9788	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SPOP_SBC_1	662:666	APSTT	SPOP	0.9984	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	684:688	APSTT	SPOP	0.9971	More...
Q9H4A9	Dipeptidase 2	DEG_SPOP_SBC_1	59:63	APSTT	SPOP	0.9878	More...
Q9NRR4	Ribonuclease 3	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9364	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	107:111	APSTT	SPOP	0.9984	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4594:4598	APSTT	SPOP	0.8747	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	263:267	APSTT	SPOP	0.5944	More...
Q6ZS72	Protein PEAK3	DEG_SPOP_SBC_1	364:368	APSTT	SPOP	0.9503	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	430:434	APSTT	SPOP	0.9498	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	421:425	APSTT	SPOP	0.9451	More...
Q96FV0	Leucine-rich repeat-containing protein 46	DEG_SPOP_SBC_1	308:312	APSTT	SPOP	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTT

Degron related mutations and impact score

Drug responses associated with DROSHA mutations

All proteins holding degron of APSTT