DegronMD

Uniprot ID: O15389

Source protein: Sialic acid-binding Ig-like lectin 5

Source gene: SIGLEC5

Class: DEG_SPOP_SBC_1

Location: 538:542

E3 ligase: SPOP

DEGRON score: 0.9802

ASA_SCORE: 82.54

COIL: 0.8496

CONS_SCORE: 0.6029

DSS_SCORE: 0.6849

HELIX: 0.0412

FCONS_SCORE: 1.0318

RIG_SCORE: 0.6288

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S540R	TCGA-50-5931	LUAD	TCGA	APSTT	DEG_SPOP_SBC_1	0.7427
p.S540R	DO229028	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	0.7427
p.S540R	DO24980	LUAD	ICGC	APSTT	DEG_SPOP_SBC_1	0.7427
p.D535G	TCGA-AA-A010	COAD	TCGA	APSTT	DEG_SPOP_SBC_1	0.25
p.S530L	TCGA-AJ-A3EL	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	0.1111
p.S530L	DO41542	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	0.1111
p.S545L	TCGA-CV-6936	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	0.6944
p.S545L	DO14210	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.6944
p.K548N	TCGA-D8-A27F	BRCA	TCGA	APSTT	DEG_SPOP_SBC_1	0.2778
p.K548N	DO1274	BRCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.2778
p.K529T	DO218031	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1944
p.K529T	DO218243	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1944
p.A538D	DO229045	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	0.7793
p.Y544C	DO231784	LINC	ICGC	APSTT	DEG_SPOP_SBC_1	0.7222
p.T549K	DO232009	ORCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1389
p.A538T	DO228138	PBCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.7139
p.E537D	DO229275	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.3056
p.P533H	DO229275	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1944
p.E532K	SIDM00545	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1667
p.E532K	SIDM00887	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	0.1667
p.E532K	ACH-000211	Brain Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	0.1667
p.E532K	ACH-000987	Skin Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	0.1667
p.E532K	Daoy	central_nervous_system	COSMIC	APSTT	DEG_SPOP_SBC_1	0.1667
p.E532K	Mewo	skin	COSMIC	APSTT	DEG_SPOP_SBC_1	0.1667
p.I547T	SIDM01483	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	140:144	APSTT	SPOP	0.8845	More...
O15389	Sialic acid-binding Ig-like lectin 5	DEG_SPOP_SBC_1	538:542	APSTT	SPOP	0.9802	More...
O43150	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	778:782	APSTT	SPOP	0.8384	More...
P49765	Vascular endothelial growth factor B	DEG_SPOP_SBC_1	179:183	APSTT	SPOP	0.9197	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	295:299	APSTT	SPOP	0.9983	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1332:1336	APSTT	SPOP	0.9016	More...
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_SPOP_SBC_1	335:339	APSTT	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6958:6962	APSTT	SPOP	0.9902	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7577:7581	APSTT	SPOP	0.9928	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	3488:3492	APSTT	SPOP	0.8928	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9773	More...
Q96M61	Melanoma-associated antigen B18	DEG_SPOP_SBC_1	67:71	APSTT	SPOP	0.9788	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SPOP_SBC_1	662:666	APSTT	SPOP	0.9984	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	684:688	APSTT	SPOP	0.9971	More...
Q9H4A9	Dipeptidase 2	DEG_SPOP_SBC_1	59:63	APSTT	SPOP	0.9878	More...
Q9NRR4	Ribonuclease 3	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9364	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	107:111	APSTT	SPOP	0.9984	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4594:4598	APSTT	SPOP	0.8747	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	263:267	APSTT	SPOP	0.5944	More...
Q6ZS72	Protein PEAK3	DEG_SPOP_SBC_1	364:368	APSTT	SPOP	0.9503	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	430:434	APSTT	SPOP	0.9498	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	421:425	APSTT	SPOP	0.9451	More...
Q96FV0	Leucine-rich repeat-containing protein 46	DEG_SPOP_SBC_1	308:312	APSTT	SPOP	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTT

Degron related mutations and impact score

Drug responses associated with SIGLEC5 mutations

All proteins holding degron of APSTT