DegronMD - Q96RL6(SIGLEC11)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L340P	TCGA-2G-AAGA	TGCT	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1389
p.E656D	TCGA-55-7995	LUAD	TCGA	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1667
p.E656D	DO45323	LUAD	ICGC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1667
p.A658E	TCGA-99-AA5R	LUAD	TCGA	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.2222
p.L340I	TCGA-AA-3984	COAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1389
p.L340I	DO9002	COAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1389
p.R335G	TCGA-C5-A1MI	CESC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2778
p.R335G	DO6249	CESC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2778
p.R653K	TCGA-CV-A45V	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.0833
p.R653K	DO52059	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.0833
p.R339G	TCGA-ER-A193	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1667
p.R339G	DO47368	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1667
p.R322C	TCGA-FI-A2D0	UCEC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1667
p.R322C	DO43891	UCEC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1667
p.E337K	TCGA-FS-A1ZF	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2222
p.E337K	DO38039	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2222
p.G327V	TCGA-FS-A1ZZ	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.3056
p.G327V	DO37412	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.3056
p.R331H	TCGA-WS-AB45	COAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7133
p.R331H	DO51734	COAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7133
p.R331H	SIDM00534	Colorectal Carcinoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7133
p.R331H	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7133
p.R331H	HT-115	large intestine	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7133
p.G330W	DO229259	THCA	ICGC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation altering degron motif	0.7825
p.I673S	SIDM00731	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1389
p.I673S	NCI-H2196	lung	COSMIC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1389
p.A658P	SIDM00103	Mesothelioma	GDSC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.2222
p.A658P	ACH-002124	Lung Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.2222
p.A658P	H2373	pleura	COSMIC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.2222
p.P657H	SIDM01318	Hepatocellular Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1944
p.P657H	ACH-001318	Liver Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	662:666	Mutation rewiring degron network	0.1944
p.R322H	SIDM01473	Plasma Cell Myeloma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.1667
p.A326T	ACH-002166	Skin Cancer	CCLE	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2778
p.A326T	MZ7-mel	skin	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	328:333	Mutation rewiring degron network	0.2778

Kaplan plot for SIGLEC11 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIGLEC11

UniProt ID: Q96RL6

Entrez ID: 114132

Protein name: Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SIGLEC11 in