DegronMD

Uniprot ID: Q96RL6

Source protein: Sialic acid-binding Ig-like lectin 11

Source gene: SIGLEC11

Class: DEG_SCF_TRCP1_1

Location: 328:333

E3 ligase: BTRC

DEGRON score: 0.5387

ASA_SCORE: 38.95

COIL: 0.2448

CONS_SCORE: 0.5579

DSS_SCORE: 0.3967

HELIX: 0.0658

FCONS_SCORE: 1.2518

RIG_SCORE: 0.7173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L340P	TCGA-2G-AAGA	TGCT	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1389
p.L340I	TCGA-AA-3984	COAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1389
p.L340I	DO9002	COAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.1389
p.R335G	TCGA-C5-A1MI	CESC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.R335G	DO6249	CESC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.R339G	TCGA-ER-A193	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.R339G	DO47368	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.R322C	TCGA-FI-A2D0	UCEC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.R322C	DO43891	UCEC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.E337K	TCGA-FS-A1ZF	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.2222
p.E337K	DO38039	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.2222
p.G327V	TCGA-FS-A1ZZ	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.3056
p.G327V	DO37412	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.3056
p.R331H	TCGA-WS-AB45	COAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.R331H	DO51734	COAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.R331H	SIDM00534	Colorectal Carcinoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.R331H	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.R331H	HT-115	large_intestine	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.G330W	DO229259	THCA	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.7825
p.R322H	SIDM01473	Plasma Cell Myeloma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.A326T	ACH-002166	Skin Cancer	CCLE	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.A326T	MZ7-mel	skin	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LC7	Sialic acid-binding Ig-like lectin 10	DEG_SCF_TRCP1_1	317:322	DSGRYT	BTRC	0.8154	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SCF_TRCP1_1	328:333	DSGRYT	BTRC	0.5387	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SCF_TRCP1_1	300:305	DSGRYT	BTRC	0.8338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons