DegronMD

Uniprot ID: Q96LC7

Source protein: Sialic acid-binding Ig-like lectin 10

Source gene: SIGLEC10

Class: DEG_SCF_TRCP1_1

Location: 317:322

E3 ligase: BTRC

DEGRON score: 0.8154

ASA_SCORE: 42.7667

COIL: 0.3087

CONS_SCORE: 0.3679

DSS_SCORE: 0.4433

HELIX: 0.0212

FCONS_SCORE: 1.0303

RIG_SCORE: 0.7088

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q332R	TCGA-06-0211	GBM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.0556
p.Q332R	DO11794	GBM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.0556
p.R320C	TCGA-44-A47B	LUAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	TCGA-AJ-A2QO	UCEC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	DO45353	LUAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	DO228138	PBCA	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	DO42177	UCEC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	SIDM00680	Colorectal Carcinoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.R320C	LS-180	large_intestine	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.719
p.L308R	TCGA-BR-8680	STAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.0833
p.L308R	DO47769	STAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.0833
p.G312W	TCGA-D1-A167	UCEC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1944
p.G312W	DO40978	UCEC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.1944
p.E309G	TCGA-D1-A17H	UCEC	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.1111
p.E309G	DO41847	UCEC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.1111
p.D317N	TCGA-EE-A2MR	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.6932
p.D317N	TCGA-W3-AA1V	SKCM	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.6932
p.D317N	DO37819	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.6932
p.D317N	DO51276	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.6932
p.A325V	TCGA-HU-A4G8	STAD	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.25
p.R324L	TCGA-S5-A6DX	BLCA	TCGA	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.R324L	DO51903	BLCA	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.H325R	DO229505	LAML	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.25
p.G325D	DO23396	LINC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.25
p.L323M	DO25199	LUAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.3056
p.G315C	DO230950	LUSC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.V322L	DO27572	LUSC	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.6765
p.V322I	DO46657	PAAD	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.7076
p.G317C	DO47407	SKCM	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.76
p.C323F	DO229211	THCA	ICGC	DSGRYT	DEG_SCF_TRCP1_1	0.3056
p.A315D	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.A315D	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.S318L	SIDM00973	Melanoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.7667
p.S318L	WM793B	skin	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.7667
p.R320H	SIDM00611	Kidney Carcinoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.7133
p.G312R	SIDM00941	Kidney Carcinoma	GDSC	DSGRYT	DEG_SCF_TRCP1_1	0.1944
p.G312R	CAKI-1	kidney	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.1944
p.R324Q	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.2778
p.P328L	NCI-H526	lung	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.P311R	YMB-1-E	breast	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.P311R	NCI-H1436	lung	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.1667
p.P317T	NCI-H2030	lung	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.7031
p.L332M	TGBC1TKB	biliary_tract	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.0556
p.H329R	LoVo	large_intestine	COSMIC	DSGRYT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96LC7	Sialic acid-binding Ig-like lectin 10	DEG_SCF_TRCP1_1	317:322	DSGRYT	BTRC	0.8154	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SCF_TRCP1_1	328:333	DSGRYT	BTRC	0.5387	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SCF_TRCP1_1	300:305	DSGRYT	BTRC	0.8338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGRYT

Degron related mutations and impact score

Drug responses associated with SIGLEC10 mutations

All proteins holding degron of DSGRYT