DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
DSGRYT
Uniprot ID:
A6NMB1
Source protein:
Sialic acid-binding Ig-like lectin 16
Source gene:
SIGLEC16
Class:
DEG_SCF_TRCP1_1
Location:
300:305
E3 ligase:
BTRC
DEGRON score:
0.8338
ASA_SCORE:
45.8167
COIL:
0.3275
CONS_SCORE:
0.6269
DSS_SCORE:
0.4349
HELIX:
0.019
FCONS_SCORE:
1.2614
RIG_SCORE:
0.7184
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SIGLEC16 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGRYT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96LC7
Sialic acid-binding Ig-like lectin 10
DEG_SCF_TRCP1_1
317:322
DSGRYT
BTRC
0.8154
More...
Q96RL6
Sialic acid-binding Ig-like lectin 11
DEG_SCF_TRCP1_1
328:333
DSGRYT
BTRC
0.5387
More...
A6NMB1
Sialic acid-binding Ig-like lectin 16
DEG_SCF_TRCP1_1
300:305
DSGRYT
BTRC
0.8338
More...