DegronMD - O15389(SIGLEC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S540R	TCGA-50-5931	LUAD	TCGA	APSTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7427
p.S540R	DO229028	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7427
p.S540R	DO24980	LUAD	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7427
p.D535G	TCGA-AA-A010	COAD	TCGA	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.25
p.S530L	TCGA-AJ-A3EL	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1111
p.S530L	DO41542	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1111
p.S545L	TCGA-CV-6936	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	538:542	Mutation blocking phosphorylation signal	0.6944
p.S545L	DO14210	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation blocking phosphorylation signal	0.6944
p.K548N	TCGA-D8-A27F	BRCA	TCGA	APSTT	DEG_SPOP_SBC_1	538:542	Mutation substituting flanking lysine	0.2778
p.K548N	DO1274	BRCA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation substituting flanking lysine	0.2778
p.K529T	DO218031	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation substituting flanking lysine	0.1944
p.K529T	DO218243	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation substituting flanking lysine	0.1944
p.A538D	DO229045	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7793
p.Y544C	DO231784	LINC	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation blocking phosphorylation signal	0.7222
p.T549K	DO232009	ORCA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1389
p.A538T	DO228138	PBCA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation altering degron motif	0.7139
p.E537D	DO229275	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.3056
p.P533H	DO229275	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1944
p.E532K	SIDM00545	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.E532K	SIDM00887	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.E532K	ACH-000211	Brain Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.E532K	ACH-000987	Skin Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.E532K	Daoy	central nervous system	COSMIC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.E532K	Mewo	skin	COSMIC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1667
p.I547T	SIDM01483	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	538:542	Mutation rewiring degron network	0.1944

Kaplan plot for SIGLEC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SIGLEC5

UniProt ID: O15389

Entrez ID: 8778

Protein name: Sialic acid-binding Ig-like lectin 5 (Siglec-5) (CD33 antigen-like 2) (Obesity-binding protein 2) (OB-BP2) (OB-binding protein 2) (CD antigen CD170)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SIGLEC5 in