DegronMD - Q6P1N0(CC2D1A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P342H	TCGA-06-5856	GBM	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.25
p.P342H	TCGA-06-5856	GBM	TCGA	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.25
p.P342H	DO13456	GBM	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.25
p.P342H	DO13456	GBM	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.25
p.P336S	TCGA-56-8622	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.5641
p.P336S	DO45449	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.5641
p.A202V	TCGA-60-2714	LUSC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.5825
p.A202V	DO26530	LUSC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.5825
p.G198E	TCGA-A2-A0YK	BRCA	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.25
p.G198E	DO2836	BRCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.25
p.P192L	TCGA-A5-A2K7	UCEC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.P192L	DO41271	UCEC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.A196V	TCGA-AA-3663	COAD	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1944
p.A196V	DO9346	COAD	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1944
p.A196V	DO50786	LICA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1944
p.P326L	TCGA-AP-A1DK	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0833
p.P326L	DO42033	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.0833
p.V361L	TCGA-BH-A0DZ	BRCA	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.V361L	DO2919	BRCA	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.1111
p.V341L	TCGA-CC-A7IH	LIHC	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2222
p.V341L	TCGA-CC-A7IH	LIHC	TCGA	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.V341L	DO52181	LIHC	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2222
p.V341L	DO52181	LIHC	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2778
p.R355Q	TCGA-E2-A574	BRCA	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2778
p.R355Q	DO49022	BRCA	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation rewiring degron network	0.2778
p.P192Q	TCGA-ER-A195	SKCM	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.P192Q	DO47712	SKCM	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.P193L	TCGA-FR-A729	SKCM	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1111
p.P193L	DO48618	SKCM	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1111
p.G200S	TCGA-UY-A78K	BLCA	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.3056
p.G200S	DO219031	BLCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.3056
p.R217K	TCGA-VS-A958	CESC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.R217K	DO51639	CESC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.0833
p.A196T	DO222755	COCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1944
p.T204M	DO233882	GACA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.8534
p.T204M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.8534
p.T204M	ACH-000995	Leukemia	CCLE	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.8534
p.T204M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation altering degron motif	0.8534
p.T331S	DO231713	LINC	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.S327W	DO231204	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation blocking phosphorylation signal	0.5556
p.T331P	DO218908	SKCA	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.T331P	ACH-000725	Breast Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.T331P	ACH-000770	Leukemia	CCLE	APSTT	DEG_SPOP_SBC_1	335:339	Mutation rewiring degron network	0.2222
p.T338S	DO229227	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.6005
p.T339P	SIDM00455	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00773	Non-Cancerous	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM01062	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00393	Gastric Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00846	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00633	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00202	Ewing's Sarcoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00210	Ovarian Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00835	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00694	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00879	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00522	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00844	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00907	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00621	Ewing's Sarcoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00954	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00863	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00774	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00673	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM00628	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM01387	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.T339P	SIDM01525	Acute Myeloid Leukemia	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7031
p.V195A	SIDM00537	Colorectal Carcinoma	GDSC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1667
p.V195A	ACH-000982	Colon/Colorectal Cancer	CCLE	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1667
p.V195A	ACH-001345	Colon/Colorectal Cancer	CCLE	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1667
p.V195A	GP5d	large intestine	COSMIC	PASTPTYS	DEG_SCF_FBW7_1	201:208	Mutation rewiring degron network	0.1667
p.T338R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7876
p.T338R	ACH-001127	Leukemia	CCLE	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7876
p.T338R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation altering degron motif	0.7876
p.L349M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.711
p.L349M	ACH-001127	Leukemia	CCLE	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.711
p.L349M	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PRTLLEALE	DEG_APCC_DBOX_1	345:353	Mutation altering degron motif	0.711
p.T334M	SIDM01770	Gastric Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	335:339	Mutation blocking phosphorylation signal	0.75
p.T334M	ACH-000908	Gastric Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	335:339	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CC2D1A

UniProt ID: Q6P1N0

Entrez ID: 54862

Protein name: Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CC2D1A in