DegronMD

Uniprot ID: Q6P1N0

Source protein: Coiled-coil and C2 domain-containing protein 1A

Source gene: CC2D1A

Class: DEG_APCC_DBOX_1

Location: 345:353

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9968

ASA_SCORE: 81.3444

COIL: 0.3708

CONS_SCORE: 0.4632

DSS_SCORE: 0.6934

HELIX: 0.6288

FCONS_SCORE: 1.369

RIG_SCORE: 0.7491

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P342H	TCGA-06-5856	GBM	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	0.25
p.P342H	DO13456	GBM	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	0.25
p.V361L	TCGA-BH-A0DZ	BRCA	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	0.1111
p.V361L	DO2919	BRCA	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	0.1111
p.V341L	TCGA-CC-A7IH	LIHC	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	0.2222
p.V341L	DO52181	LIHC	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	0.2222
p.R355Q	TCGA-E2-A574	BRCA	TCGA	PRTLLEALE	DEG_APCC_DBOX_1	0.2778
p.R355Q	DO49022	BRCA	ICGC	PRTLLEALE	DEG_APCC_DBOX_1	0.2778
p.L349M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PRTLLEALE	DEG_APCC_DBOX_1	0.711
p.L349M	ACH-001127	Leukemia	CCLE	PRTLLEALE	DEG_APCC_DBOX_1	0.711
p.L349M	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PRTLLEALE	DEG_APCC_DBOX_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_APCC_DBOX_1	345:353	PRTLLEALE	APC,CDC20,FZR1	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons