DegronMD

Uniprot ID: Q6P1N0

Source protein: Coiled-coil and C2 domain-containing protein 1A

Source gene: CC2D1A

Class: DEG_SPOP_SBC_1

Location: 335:339

E3 ligase: SPOP

DEGRON score: 0.9552

ASA_SCORE: 88.02

COIL: 0.9524

CONS_SCORE: 0.2601

DSS_SCORE: 0.8723

HELIX: 0.0144

FCONS_SCORE: 0.8193

RIG_SCORE: 0.5233

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P342H	TCGA-06-5856	GBM	TCGA	APSTT	DEG_SPOP_SBC_1	0.25
p.P342H	DO13456	GBM	ICGC	APSTT	DEG_SPOP_SBC_1	0.25
p.P336S	TCGA-56-8622	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	0.5641
p.P336S	DO45449	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.5641
p.P326L	TCGA-AP-A1DK	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	0.0833
p.P326L	DO42033	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	0.0833
p.V341L	TCGA-CC-A7IH	LIHC	TCGA	APSTT	DEG_SPOP_SBC_1	0.2778
p.V341L	DO52181	LIHC	ICGC	APSTT	DEG_SPOP_SBC_1	0.2778
p.T331S	DO231713	LINC	ICGC	APSTT	DEG_SPOP_SBC_1	0.2222
p.S327W	DO231204	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.5556
p.T331P	DO218908	SKCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.2222
p.T331P	ACH-000725	Breast Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	0.2222
p.T331P	ACH-000770	Leukemia	CCLE	APSTT	DEG_SPOP_SBC_1	0.2222
p.T338S	DO229227	THCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.6005
p.T339P	SIDM00455	Pancreatic Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00773	Non-Cancerous	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM01062	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00393	Gastric Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00846	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00633	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00202	Ewing's Sarcoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00210	Ovarian Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00835	Colorectal Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00694	Other Solid Cancers	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00879	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00522	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00844	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00907	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00621	Ewing's Sarcoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00954	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00863	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00774	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00673	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM00628	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM01387	Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T339P	SIDM01525	Acute Myeloid Leukemia	GDSC	APSTT	DEG_SPOP_SBC_1	0.7031
p.T338R	SIDM00145	T-Lymphoblastic Leukemia	GDSC	APSTT	DEG_SPOP_SBC_1	0.7876
p.T338R	ACH-001127	Leukemia	CCLE	APSTT	DEG_SPOP_SBC_1	0.7876
p.T338R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	APSTT	DEG_SPOP_SBC_1	0.7876
p.T334M	SIDM01770	Gastric Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.75
p.T334M	ACH-000908	Gastric Cancer	CCLE	APSTT	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	140:144	APSTT	SPOP	0.8845	More...
O15389	Sialic acid-binding Ig-like lectin 5	DEG_SPOP_SBC_1	538:542	APSTT	SPOP	0.9802	More...
O43150	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	778:782	APSTT	SPOP	0.8384	More...
P49765	Vascular endothelial growth factor B	DEG_SPOP_SBC_1	179:183	APSTT	SPOP	0.9197	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	295:299	APSTT	SPOP	0.9983	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1332:1336	APSTT	SPOP	0.9016	More...
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_SPOP_SBC_1	335:339	APSTT	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6958:6962	APSTT	SPOP	0.9902	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7577:7581	APSTT	SPOP	0.9928	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	3488:3492	APSTT	SPOP	0.8928	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9773	More...
Q96M61	Melanoma-associated antigen B18	DEG_SPOP_SBC_1	67:71	APSTT	SPOP	0.9788	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SPOP_SBC_1	662:666	APSTT	SPOP	0.9984	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	684:688	APSTT	SPOP	0.9971	More...
Q9H4A9	Dipeptidase 2	DEG_SPOP_SBC_1	59:63	APSTT	SPOP	0.9878	More...
Q9NRR4	Ribonuclease 3	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9364	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	107:111	APSTT	SPOP	0.9984	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4594:4598	APSTT	SPOP	0.8747	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	263:267	APSTT	SPOP	0.5944	More...
Q6ZS72	Protein PEAK3	DEG_SPOP_SBC_1	364:368	APSTT	SPOP	0.9503	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	430:434	APSTT	SPOP	0.9498	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	421:425	APSTT	SPOP	0.9451	More...
Q96FV0	Leucine-rich repeat-containing protein 46	DEG_SPOP_SBC_1	308:312	APSTT	SPOP	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTT

Degron related mutations and impact score

Drug responses associated with CC2D1A mutations

All proteins holding degron of APSTT