DegronMD

Uniprot ID: Q9BYB0

Source protein: SH3 and multiple ankyrin repeat domains protein 3

Source gene: SHANK3

Class: DEG_SPOP_SBC_1

Location: 684:688

E3 ligase: SPOP

DEGRON score: 0.9971

ASA_SCORE: 85.62

COIL: 0.9324

CONS_SCORE: 0.5447

DSS_SCORE: 0.77

HELIX: 0.042

FCONS_SCORE: 1.0941

RIG_SCORE: 0.6315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R682M	TCGA-63-6202	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	0.2778
p.R682M	DO26560	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.2778
p.R682S	TCGA-63-6202	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	0.2778
p.R682S	DO26560	LUSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.2778
p.V674I	TCGA-AJ-A3EK	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	0.0556
p.V674I	DO41584	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	0.0556
p.G688W	TCGA-CV-5441	HNSC	TCGA	APSTT	DEG_SPOP_SBC_1	0.7825
p.G688W	DO15671	HNSC	ICGC	APSTT	DEG_SPOP_SBC_1	0.7825
p.V677D	DO222995	BTCA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1389
p.A689V	DO234417	ESAD	ICGC	APSTT	DEG_SPOP_SBC_1	0.3056
p.A689V	DO233652	GACA	ICGC	APSTT	DEG_SPOP_SBC_1	0.3056
p.V677F	DO228948	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1389
p.V678L	DO228974	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	0.1667
p.R690L	DO229018	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	0.7222
p.R674C	SIDM00889	Cervical Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	0.0556
p.R674C	C-33-A	cervix	COSMIC	APSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15226	NF-kappa-B-repressing factor	DEG_SPOP_SBC_1	140:144	APSTT	SPOP	0.8845	More...
O15389	Sialic acid-binding Ig-like lectin 5	DEG_SPOP_SBC_1	538:542	APSTT	SPOP	0.9802	More...
O43150	Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	778:782	APSTT	SPOP	0.8384	More...
P49765	Vascular endothelial growth factor B	DEG_SPOP_SBC_1	179:183	APSTT	SPOP	0.9197	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	295:299	APSTT	SPOP	0.9983	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1332:1336	APSTT	SPOP	0.9016	More...
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_SPOP_SBC_1	335:339	APSTT	SPOP	0.9552	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	6958:6962	APSTT	SPOP	0.9902	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7577:7581	APSTT	SPOP	0.9928	More...
Q96JG9	Zinc finger protein 469	DEG_SPOP_SBC_1	3488:3492	APSTT	SPOP	0.8928	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9773	More...
Q96M61	Melanoma-associated antigen B18	DEG_SPOP_SBC_1	67:71	APSTT	SPOP	0.9788	More...
Q96RL6	Sialic acid-binding Ig-like lectin 11	DEG_SPOP_SBC_1	662:666	APSTT	SPOP	0.9984	More...
Q9BYB0	SH3 and multiple ankyrin repeat domains protein 3	DEG_SPOP_SBC_1	684:688	APSTT	SPOP	0.9971	More...
Q9H4A9	Dipeptidase 2	DEG_SPOP_SBC_1	59:63	APSTT	SPOP	0.9878	More...
Q9NRR4	Ribonuclease 3	DEG_SPOP_SBC_1	58:62	APSTT	SPOP	0.9364	More...
Q9NRR5	Ubiquilin-4	DEG_SPOP_SBC_1	107:111	APSTT	SPOP	0.9984	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	4594:4598	APSTT	SPOP	0.8747	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	263:267	APSTT	SPOP	0.5944	More...
Q6ZS72	Protein PEAK3	DEG_SPOP_SBC_1	364:368	APSTT	SPOP	0.9503	More...
Q8WUT4	Leucine-rich repeat neuronal protein 4	DEG_SPOP_SBC_1	430:434	APSTT	SPOP	0.9498	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	421:425	APSTT	SPOP	0.9451	More...
Q96FV0	Leucine-rich repeat-containing protein 46	DEG_SPOP_SBC_1	308:312	APSTT	SPOP	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APSTT

Degron related mutations and impact score

Drug responses associated with SHANK3 mutations

All proteins holding degron of APSTT