DegronMD - Q9NRR5(UBQLN4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S516F	TCGA-18-3409	LUSC	TCGA	APTSS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.7982
p.S516F	TCGA-FR-A726	SKCM	TCGA	APTSS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.7982
p.S516F	DO26444	LUSC	ICGC	APTSS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.7982
p.S516F	DO48665	SKCM	ICGC	APTSS	DEG_SPOP_SBC_1	513:517	Mutation altering degron motif	0.7982
p.T520M	TCGA-A5-A0G2	UCEC	TCGA	PATPATS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7423
p.T520M	DO41235	UCEC	ICGC	PATPATS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.7423
p.A519T	TCGA-A5-A0VP	UCEC	TCGA	PATPATS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.6028
p.A519T	DO42600	UCEC	ICGC	PATPATS	DEG_SCF_FBW7_1	518:524	Mutation altering degron motif	0.6028
p.R497Q	TCGA-B5-A3FC	UCEC	TCGA	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6218
p.R497Q	DO41871	UCEC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6218
p.L490V	TCGA-DK-A1AD	BLCA	TCGA	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.1944
p.L490V	DO459	BLCA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.1944
p.A107T	TCGA-E6-A2P9	UCEC	TCGA	APSTT	DEG_SPOP_SBC_1	107:111	Mutation altering degron motif	0.7139
p.A107T	DO43714	UCEC	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation altering degron motif	0.7139
p.P99T	TCGA-G4-6588	COAD	TCGA	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1111
p.P99T	DO10140	COAD	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1111
p.I495M	DO228483	BRCA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO229346	LAML	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO229489	LAML	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO228947	LICA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO230550	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO230993	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO231049	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.I495M	DO35270	PACA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6507
p.A116T	DO48223	ESCA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1944
p.A107E	DO228976	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation altering degron motif	0.7701
p.P115H	DO229028	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.2222
p.A500E	DO229022	LICA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.659
p.Q535K	DO229027	LICA	ICGC	PATSS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.0556
p.A116D	DO229036	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1944
p.P102H	DO229006	LICA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1944
p.A500T	DO23440	LINC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6028
p.L490F	DO220851	MELA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation rewiring degron network	0.1944
p.P102A	DO33084	PACA	ICGC	APSTT	DEG_SPOP_SBC_1	107:111	Mutation rewiring degron network	0.1944
p.P501H	SIDM00633	Breast Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6583
p.P501H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6583
p.P501H	SIDM01752	Pancreatic Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	495:502	Mutation altering degron motif	0.6583

Kaplan plot for UBQLN4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBQLN4

UniProt ID: Q9NRR5

Entrez ID: 56893

Protein name: Ubiquilin-4 (Ataxin-1 interacting ubiquitin-like protein) (A1Up) (Ataxin-1 ubiquitin-like-interacting protein A1U) (Connexin43-interacting protein of 75 kDa) (CIP75)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBQLN4 in