DegronMD

Uniprot ID: Q9NRR5

Source protein: Ubiquilin-4

Source gene: UBQLN4

Class: DEG_SCF_FBW7_1

Location: 518:524

E3 ligase: FBXW7

DEGRON score: 0.9921

ASA_SCORE: 71.1143

COIL: 0.9063

CONS_SCORE: 0.3134

DSS_SCORE: 0.7675

HELIX: 0.0623

FCONS_SCORE: 1.2441

RIG_SCORE: 0.5441

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T520M	TCGA-A5-A0G2	UCEC	TCGA	PATPATS	DEG_SCF_FBW7_1	0.7423
p.T520M	DO41235	UCEC	ICGC	PATPATS	DEG_SCF_FBW7_1	0.7423
p.A519T	TCGA-A5-A0VP	UCEC	TCGA	PATPATS	DEG_SCF_FBW7_1	0.6028
p.A519T	DO42600	UCEC	ICGC	PATPATS	DEG_SCF_FBW7_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRR5	Ubiquilin-4	DEG_SCF_FBW7_1	518:524	PATPATS	FBXW7	0.9921	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons