DegronMD

Uniprot ID: Q9NRR5

Source protein: Ubiquilin-4

Source gene: UBQLN4

Class: DEG_SCF_FBW7_1

Location: 495:502

E3 ligase: FBXW7

DEGRON score: 0.9783

ASA_SCORE: 68.3125

COIL: 0.8891

CONS_SCORE: 0.275

DSS_SCORE: 0.5745

HELIX: 0.0396

FCONS_SCORE: 1.0802

RIG_SCORE: 0.611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R497Q	TCGA-B5-A3FC	UCEC	TCGA	ISRTPAPS	DEG_SCF_FBW7_1	0.6218
p.R497Q	DO41871	UCEC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6218
p.L490V	TCGA-DK-A1AD	BLCA	TCGA	ISRTPAPS	DEG_SCF_FBW7_1	0.1944
p.L490V	DO459	BLCA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.1944
p.I495M	DO228483	BRCA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO229346	LAML	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO229489	LAML	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO228947	LICA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO230550	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO230993	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO231049	LUSC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.I495M	DO35270	PACA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6507
p.A500E	DO229022	LICA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.659
p.A500T	DO23440	LINC	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.6028
p.L490F	DO220851	MELA	ICGC	ISRTPAPS	DEG_SCF_FBW7_1	0.1944
p.P501H	SIDM00633	Breast Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	0.6583
p.P501H	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	0.6583
p.P501H	SIDM01752	Pancreatic Carcinoma	GDSC	ISRTPAPS	DEG_SCF_FBW7_1	0.6583

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRR5	Ubiquilin-4	DEG_SCF_FBW7_1	495:502	ISRTPAPS	FBXW7	0.9783	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons