DegronMD

Uniprot ID: Q6P1N0

Source protein: Coiled-coil and C2 domain-containing protein 1A

Source gene: CC2D1A

Class: DEG_SCF_FBW7_1

Location: 201:208

E3 ligase: FBXW7

DEGRON score: 0.9767

ASA_SCORE: 96.05

COIL: 0.9598

CONS_SCORE: 0.2623

DSS_SCORE: 0.6565

HELIX: 0.0115

FCONS_SCORE: 0.7603

RIG_SCORE: 0.5781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A202V	TCGA-60-2714	LUSC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.5825
p.A202V	DO26530	LUSC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.5825
p.G198E	TCGA-A2-A0YK	BRCA	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.25
p.G198E	DO2836	BRCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.25
p.P192L	TCGA-A5-A2K7	UCEC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.P192L	DO41271	UCEC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.A196V	TCGA-AA-3663	COAD	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.1944
p.A196V	DO9346	COAD	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.1944
p.A196V	DO50786	LICA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.1944
p.P192Q	TCGA-ER-A195	SKCM	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.P192Q	DO47712	SKCM	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.P193L	TCGA-FR-A729	SKCM	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.1111
p.P193L	DO48618	SKCM	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.1111
p.G200S	TCGA-UY-A78K	BLCA	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.3056
p.G200S	DO219031	BLCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.3056
p.R217K	TCGA-VS-A958	CESC	TCGA	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.R217K	DO51639	CESC	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.0833
p.A196T	DO222755	COCA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.1944
p.T204M	DO233882	GACA	ICGC	PASTPTYS	DEG_SCF_FBW7_1	0.8534
p.T204M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PASTPTYS	DEG_SCF_FBW7_1	0.8534
p.T204M	ACH-000995	Leukemia	CCLE	PASTPTYS	DEG_SCF_FBW7_1	0.8534
p.T204M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PASTPTYS	DEG_SCF_FBW7_1	0.8534
p.V195A	SIDM00537	Colorectal Carcinoma	GDSC	PASTPTYS	DEG_SCF_FBW7_1	0.1667
p.V195A	ACH-000982	Colon/Colorectal Cancer	CCLE	PASTPTYS	DEG_SCF_FBW7_1	0.1667
p.V195A	ACH-001345	Colon/Colorectal Cancer	CCLE	PASTPTYS	DEG_SCF_FBW7_1	0.1667
p.V195A	GP5d	large_intestine	COSMIC	PASTPTYS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1N0	Coiled-coil and C2 domain-containing protein 1A	DEG_SCF_FBW7_1	201:208	PASTPTYS	FBXW7	0.9767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PASTPTYS

Degron related mutations and impact score

Drug responses associated with CC2D1A mutations

All proteins holding degron of PASTPTYS