DegronMD - O95171(SCEL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q210H	TCGA-17-Z026	LUAD	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1944
p.N341K	TCGA-24-2254	OV	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.R613W	TCGA-5C-A9VG	LIHC	TCGA	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.R613W	DO52163	LIHC	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.P165S	TCGA-66-2766	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.P165S	TCGA-66-2766	LUSC	TCGA	PPGY	ITCH	168:171	Mutation rewiring degron network	0.25
p.P165S	DO27747	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.P165S	DO27747	LUSC	ICGC	PPGY	ITCH	168:171	Mutation rewiring degron network	0.25
p.E597D	TCGA-AG-A002	READ	TCGA	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.E597D	DO229025	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.E331K	TCGA-AN-A046	BRCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	TCGA-AP-A056	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	TCGA-EE-A2GP	SKCM	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	TCGA-EY-A1G8	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	DO1285	BRCA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	DO37422	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	DO43578	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.E331K	DO43971	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.591
p.R319S	TCGA-AP-A0LM	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.Q328H	TCGA-AX-A05Z	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.647
p.R319M	TCGA-AX-A0J0	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.R319M	DO41133	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.R160M	TCGA-BS-A0UV	UCEC	TCGA	PPGY	ITCH	168:171	Mutation rewiring degron network	0.1111
p.R160M	DO42793	UCEC	ICGC	PPGY	ITCH	168:171	Mutation rewiring degron network	0.1111
p.R618K	TCGA-BS-A0UV	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.R618K	DO42793	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.1389
p.R613S	TCGA-CQ-7064	HNSC	TCGA	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.R613S	DO14162	HNSC	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.R613S	DO229045	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.2778
p.R228I	TCGA-E6-A1LX	UCEC	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1389
p.R228I	DO41020	UCEC	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.1389
p.G185C	TCGA-EE-A181	SKCM	TCGA	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.G185C	DO37444	SKCM	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.T320S	TCGA-EM-A22L	THCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1667
p.R224K	TCGA-FS-A4FD	SKCM	TCGA	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.25
p.R224K	DO37699	SKCM	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.25
p.H187Y	TCGA-GV-A3JZ	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.H187Y	DO773	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.Q328R	TCGA-HD-7754	HNSC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.6218
p.Q318K	TCGA-KQ-A41N	BLCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1111
p.I604V	TCGA-VR-A8EZ	ESCA	TCGA	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.25
p.H187N	TCGA-XF-A9SK	BLCA	TCGA	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.H187N	DO223596	BLCA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.H187N	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.H187N	ACH-002337	Lung Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0556
p.G344E	DO7852	COAD	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation blocking phosphorylation signal	0.5
p.N341T	DO8730	COAD	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.V607A	DO227634	COCA	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation altering degron motif	0.5825
p.F164V	DO223109	ESCA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.0833
p.F164V	DO223109	ESCA	ICGC	PPGY	ITCH	168:171	Mutation rewiring degron network	0.2222
p.S225F	DO233634	GACA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.G344V	DO229027	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation blocking phosphorylation signal	0.5
p.A331S	DO229031	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.7588
p.A173S	DO229031	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7588
p.A173S	DO46697	PACA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7588
p.V336L	DO229037	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.2778
p.K158N	DO229045	LICA	ICGC	PPGY	ITCH	168:171	Mutation substituting flanking lysine	0.1667
p.V333F	DO229006	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.7068
p.P169S	DO50788	LICA	ICGC	PPGY	ITCH	168:171	Mutation altering degron motif	0.6752
p.P216S	DO50927	LICA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.5641
p.V334L	DO27088	LUSC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.6765
p.P213S	DO220878	MELA	ICGC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2778
p.G326R	DO220877	MELA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.6457
p.E340K	DO220881	MELA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1667
p.S175L	DO27887	ORCA	ICGC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation altering degron motif	0.7667
p.N319K	DO29156	OV	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1389
p.C621G	DO34136	PACA	ICGC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0556
p.S327N	DO47485	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation altering degron motif	0.7069
p.P338L	DO47619	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.2222
p.V316A	SIDM01296	Esophageal Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.0556
p.S344N	SIDM00499	Prostate Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation blocking phosphorylation signal	0.5
p.S344N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation blocking phosphorylation signal	0.5
p.P165L	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.P165L	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	168:171	Mutation rewiring degron network	0.25
p.P165L	SIDM00171	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1111
p.P165L	SIDM00171	Colorectal Carcinoma	GDSC	PPGY	ITCH	168:171	Mutation rewiring degron network	0.25
p.E221G	SIDM00337	Melanoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00195	Ewing's Sarcoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00177	Melanoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00312	Plasma Cell Myeloma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.E221G	SIDM01504	Small Cell Lung Carcinoma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation altering degron motif	0.7199
p.R182W	SIDM00049	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1944
p.R182W	DIFI	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1944
p.R182Q	SIDM00217	Colorectal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1944
p.R182Q	SNU-1040	large intestine	COSMIC	ASSST	DEG_SPOP_SBC_1	173:177	Mutation rewiring degron network	0.1944
p.I211M	SIDM00575	Glioma	GDSC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.I211M	ACH-000200	Brain Cancer	CCLE	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.I211M	NMC-G1	central nervous system	COSMIC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.2222
p.P168H	SIDM01494	Glioblastoma	GDSC	PPGY	ITCH	168:171	Mutation altering degron motif	0.7694
p.P168H	ACH-000445	Brain Cancer	CCLE	PPGY	ITCH	168:171	Mutation altering degron motif	0.7694
p.R339M	SIDM00497	Colorectal Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1944
p.R339M	ACH-000683	Colon/Colorectal Cancer	CCLE	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1944
p.Q620H	HCC2998	large intestine	COSMIC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.H602Q	HDQ-P1	breast	COSMIC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation substituting flanking lysine	0.3056
p.K339I	LB647-SCLC	lung	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.1944
p.S322N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation substituting flanking lysine	0.3333
p.S231R	LoVo	large intestine	COSMIC	KPGVYTE	LIG_APCC_ABBAyCdc20_2	215:221	Mutation rewiring degron network	0.0556
p.S324N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.2778
p.Q598H	HCC2998	large intestine	COSMIC	VYSTS	DEG_SPOP_SBC_1	607:611	Mutation rewiring degron network	0.0833
p.K337I	LB647-SCLC	lung	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	326:334	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCEL

UniProt ID: O95171

Entrez ID: 8796

Protein name: Sciellin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCEL in