DegronMD

Uniprot ID: O95171

Source protein: Sciellin

Source gene: SCEL

Class: DEG_APCC_DBOX_1

Location: 326:334

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9612

ASA_SCORE: 84.4556

COIL: 0.5954

CONS_SCORE: 0.4479

DSS_SCORE: 0.6448

HELIX: 0.3499

FCONS_SCORE: 1.0756

RIG_SCORE: 0.7229

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N341K	TCGA-24-2254	OV	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.E331K	TCGA-AN-A046	BRCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	TCGA-AP-A056	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	TCGA-EE-A2GP	SKCM	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	TCGA-EY-A1G8	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	DO1285	BRCA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	DO37422	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	DO43578	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.E331K	DO43971	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.591
p.R319S	TCGA-AP-A0LM	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.Q328H	TCGA-AX-A05Z	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.647
p.R319M	TCGA-AX-A0J0	UCEC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.R319M	DO41133	UCEC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.T320S	TCGA-EM-A22L	THCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.1667
p.Q328R	TCGA-HD-7754	HNSC	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.6218
p.Q318K	TCGA-KQ-A41N	BLCA	TCGA	GRQNLESVA	DEG_APCC_DBOX_1	0.1111
p.G344E	DO7852	COAD	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.5
p.N341T	DO8730	COAD	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.G344V	DO229027	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.5
p.A331S	DO229031	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.7588
p.V336L	DO229037	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.2778
p.V333F	DO229006	LICA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.7068
p.V334L	DO27088	LUSC	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.6765
p.G326R	DO220877	MELA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.6457
p.E340K	DO220881	MELA	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.1667
p.N319K	DO29156	OV	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.1389
p.S327N	DO47485	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.7069
p.P338L	DO47619	SKCM	ICGC	GRQNLESVA	DEG_APCC_DBOX_1	0.2222
p.V316A	SIDM01296	Esophageal Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	0.0556
p.S344N	SIDM00499	Prostate Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	0.5
p.S344N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	0.5
p.R339M	SIDM00497	Colorectal Carcinoma	GDSC	GRQNLESVA	DEG_APCC_DBOX_1	0.1944
p.R339M	ACH-000683	Colon/Colorectal Cancer	CCLE	GRQNLESVA	DEG_APCC_DBOX_1	0.1944
p.K339I	LB647-SCLC	lung	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	0.1944
p.S322N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	0.3333
p.S324N	22RV1	prostate	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	0.2778
p.K337I	LB647-SCLC	lung	COSMIC	GRQNLESVA	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRQNLESVA

Degron related mutations and impact score

Drug responses associated with SCEL mutations

All proteins holding degron of GRQNLESVA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95171	Sciellin	DEG_APCC_DBOX_1	326:334	GRQNLESVA	APC,CDC20,FZR1	0.9612	More...