DegronMD

Uniprot ID: O95171

Source protein: Sciellin

Source gene: SCEL

Class: DEG_SPOP_SBC_1

Location: 607:611

E3 ligase: SPOP

DEGRON score: 0.931

ASA_SCORE: 63.08

COIL: 0.626

CONS_SCORE: 0.8468

DSS_SCORE: 0.3044

HELIX: 0.0998

FCONS_SCORE: 1.164

RIG_SCORE: 0.8023

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R613W	TCGA-5C-A9VG	LIHC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.2778
p.R613W	DO52163	LIHC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2778
p.E597D	TCGA-AG-A002	READ	TCGA	VYSTS	DEG_SPOP_SBC_1	0.0556
p.E597D	DO229025	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.R618K	TCGA-BS-A0UV	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.1389
p.R618K	DO42793	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.1389
p.R613S	TCGA-CQ-7064	HNSC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.2778
p.R613S	DO14162	HNSC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2778
p.R613S	DO229045	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2778
p.I604V	TCGA-VR-A8EZ	ESCA	TCGA	VYSTS	DEG_SPOP_SBC_1	0.25
p.V607A	DO227634	COCA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.5825
p.C621G	DO34136	PACA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.Q620H	HCC2998	large_intestine	COSMIC	VYSTS	DEG_SPOP_SBC_1	0.0833
p.H602Q	HDQ-P1	breast	COSMIC	VYSTS	DEG_SPOP_SBC_1	0.3056
p.Q598H	HCC2998	large_intestine	COSMIC	VYSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95171	Sciellin	DEG_SPOP_SBC_1	607:611	VYSTS	SPOP	0.931	More...
Q7Z794	Keratin, type II cytoskeletal 1b	DEG_SPOP_SBC_1	18:22	VYSTS	SPOP	0.7206	More...
Q9H299	SH3 domain-binding glutamic acid-rich-like protein 3	DEG_SPOP_SBC_1	6:10	VYSTS	SPOP	0.638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons