DegronMD - Q7Z794(KRT77)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P32L	TCGA-AF-A56L	READ	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.P32L	TCGA-EE-A29D	SKCM	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.P32L	DO50276	READ	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.P32L	DO38123	SKCM	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.P32L	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.P32L	NCI-H1703	lung	COSMIC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.S15N	TCGA-AP-A1DV	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.S15N	DO232224	PBCA	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.S15N	DO43186	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.M14T	TCGA-BS-A0UJ	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.M14T	DO42745	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.F11L	TCGA-D1-A103	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.F11L	DO42312	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.A25V	TCGA-EC-A24G	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.A25V	DO40996	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.E212D	TCGA-EY-A1G8	UCEC	TCGA	VNTST	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.E212D	DO43578	UCEC	ICGC	VNTST	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.G29D	TCGA-F7-A624	HNSC	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.G29D	DO44440	HNSC	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.S9F	TCGA-FR-A726	SKCM	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.S9F	DO48665	SKCM	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.Q8E	TCGA-GU-A766	BLCA	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.Q8E	DO51891	BLCA	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.S23C	TCGA-XF-A8HD	BLCA	TCGA	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.75
p.S23C	DO49795	BLCA	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation blocking phosphorylation signal	0.75
p.S205L	DO1071	BRCA	ICGC	VNTST	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7667
p.P32S	DO234285	ESAD	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.T21S	DO233767	GACA	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.6005
p.L192I	DO229015	LICA	ICGC	VNTST	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0556
p.S24Y	DO229031	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2778
p.T208N	SIDM00357	Small Cell Lung Carcinoma	GDSC	VNTST	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2778
p.T208N	SIDM00566	Oral Cavity Carcinoma	GDSC	VNTST	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT77

UniProt ID: Q7Z794

Entrez ID: 374454

Protein name: Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT77 in