DegronMD

Uniprot ID: Q7Z794

Source protein: Keratin, type II cytoskeletal 1b

Source gene: KRT77

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.7206

ASA_SCORE: 73.18

COIL: 0.57

CONS_SCORE: 0.4923

DSS_SCORE: 0.4102

HELIX: 0.0518

FCONS_SCORE: 1.0195

RIG_SCORE: 0.6882

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P32L	TCGA-AF-A56L	READ	TCGA	VYSTS	DEG_SPOP_SBC_1	0.0556
p.P32L	TCGA-EE-A29D	SKCM	TCGA	VYSTS	DEG_SPOP_SBC_1	0.0556
p.P32L	DO50276	READ	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.P32L	DO38123	SKCM	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.P32L	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.P32L	NCI-H1703	lung	COSMIC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.S15N	TCGA-AP-A1DV	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.25
p.S15N	DO232224	PBCA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.25
p.S15N	DO43186	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.25
p.M14T	TCGA-BS-A0UJ	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.2222
p.M14T	DO42745	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2222
p.F11L	TCGA-D1-A103	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.1389
p.F11L	DO42312	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.1389
p.A25V	TCGA-EC-A24G	UCEC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.25
p.A25V	DO40996	UCEC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.25
p.G29D	TCGA-F7-A624	HNSC	TCGA	VYSTS	DEG_SPOP_SBC_1	0.1389
p.G29D	DO44440	HNSC	ICGC	VYSTS	DEG_SPOP_SBC_1	0.1389
p.S9F	TCGA-FR-A726	SKCM	TCGA	VYSTS	DEG_SPOP_SBC_1	0.0833
p.S9F	DO48665	SKCM	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0833
p.Q8E	TCGA-GU-A766	BLCA	TCGA	VYSTS	DEG_SPOP_SBC_1	0.0556
p.Q8E	DO51891	BLCA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.S23C	TCGA-XF-A8HD	BLCA	TCGA	VYSTS	DEG_SPOP_SBC_1	0.75
p.S23C	DO49795	BLCA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.75
p.P32S	DO234285	ESAD	ICGC	VYSTS	DEG_SPOP_SBC_1	0.0556
p.T21S	DO233767	GACA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.6005
p.S24Y	DO229031	LICA	ICGC	VYSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95171	Sciellin	DEG_SPOP_SBC_1	607:611	VYSTS	SPOP	0.931	More...
Q7Z794	Keratin, type II cytoskeletal 1b	DEG_SPOP_SBC_1	18:22	VYSTS	SPOP	0.7206	More...
Q9H299	SH3 domain-binding glutamic acid-rich-like protein 3	DEG_SPOP_SBC_1	6:10	VYSTS	SPOP	0.638	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons